Words similar to locoregional
Example sentences for: locoregional
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As many as 30% of patients with breast cancer who have undergone curative surgery and show no evidence of locoregional or distant disease still have recurrent disease over 5-10 years [ 1 2 ] . Some of these treatment failures may be attributed to residual disease in the breast or axillary lymph nodes [ 3 ] . The limitation of routine histopathologic examination of the tumor margins and the dissected lymph node specimen is well known [ 4 ] . Contemporary methods of detection, including computed tomography, magnetic resonance imaging, bone scintigraphy and flow cytometry, all have limited sensitivity and specificity [ 5 6 ] . Micrometastases can be found by immunohistochemistry or polymerase chain reaction in 10-30% of the patients previously deemed free of disease by conventional histological methods [ 7 8 ] . The prognostic importance of micrometastases found with these sensitive methods are now being evaluated [ 9 10 11 ] .
Patients in the radiotherapy (RT), loss of heterozygosity (LOH) group had significantly lower 5 year relapse-free survival {23% (95% CI: 2% to 44%) vs. 69% (95% CI: 46% to 92%); p = 0.02} (Figure 2), locoregional control {34% (95% CI: 11% to 57%) vs. 75% (95% CI: 54% to 98%); p = 0.03} (Figure 3) and cause specific survival {29% (95% CI: 5% to 53%) vs. 75% (95% CI: 54% to 96%); p = 0.02} (Figure 4) than those in the RT, non LOH group.
Patients in the CM, LOH group had 5 year relapse-free survival, locoregional control and cause specific survival that were statistically indistinguishable from those in the CM, non LOH group (p > 0.2).
The clinical trial from which the tumor specimens used in this study were derived showed improvements in relapse-free survival, locoregional control, and overall survival for those patients randomized to combined modality therapy [ 31 ] . This investigation established that patients whose tumors had M6P/IGF2R loss of heterozygosity and were treated with radiotherapy alone had a significantly worse prognosis than their counterparts with a non-mutated allele.
Patients in the RT, LOH group also fared worse than those in the combined modality (CM), LOH group, although the differences were not statistically significant in these smaller subgroups: 5 year relapse-free survival {23% (95% CI: 2% to 44%) vs. 54% (95% CI: 26% to 82%); p = 0.18}, locoregional control {34% (95% CI: 11% to 57%) vs. 61% (95% CI: 34% to 88%); p = 0.25} and cause specific survival {29% (95% CI: 5% to 53%) vs. 59% (95% CI: 30% to 88%); p = 0.12}.
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