Words similar to locoregional
Example sentences for: locoregional
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Patients in the radiotherapy (RT), loss of heterozygosity (LOH) group had significantly lower 5 year relapse-free survival {23% (95% CI: 2% to 44%) vs. 69% (95% CI: 46% to 92%); p = 0.02} (Figure 2), locoregional control {34% (95% CI: 11% to 57%) vs. 75% (95% CI: 54% to 98%); p = 0.03} (Figure 3) and cause specific survival {29% (95% CI: 5% to 53%) vs. 75% (95% CI: 54% to 96%); p = 0.02} (Figure 4) than those in the RT, non LOH group.
M6P/IGF2R loss of heterozygosity was associated with significant reductions in 5 year relapse-free survival {37% (95% CI: 20% to 54%) vs. 65% (95% CI: 46% to 84%); p = 0.05}, locoregional control {46% (95% CI: 28% to 64%) vs. 76% (95% CI: 58% to 94%); p = 0.03} and a non-significant reduction in cause-specific survival {43% (95% CI: 25% to 61%) vs. 69% (95% CI: 49% to 89%); p = 0.1}.
The clinical trial from which the tumor specimens used in this study were derived showed improvements in relapse-free survival, locoregional control, and overall survival for those patients randomized to combined modality therapy [ 31 ] . This investigation established that patients whose tumors had M6P/IGF2R loss of heterozygosity and were treated with radiotherapy alone had a significantly worse prognosis than their counterparts with a non-mutated allele.
As many as 30% of patients with breast cancer who have undergone curative surgery and show no evidence of locoregional or distant disease still have recurrent disease over 5-10 years [ 1 2 ] . Some of these treatment failures may be attributed to residual disease in the breast or axillary lymph nodes [ 3 ] . The limitation of routine histopathologic examination of the tumor margins and the dissected lymph node specimen is well known [ 4 ] . Contemporary methods of detection, including computed tomography, magnetic resonance imaging, bone scintigraphy and flow cytometry, all have limited sensitivity and specificity [ 5 6 ] . Micrometastases can be found by immunohistochemistry or polymerase chain reaction in 10-30% of the patients previously deemed free of disease by conventional histological methods [ 7 8 ] . The prognostic importance of micrometastases found with these sensitive methods are now being evaluated [ 9 10 11 ] .
Patients in the RT, LOH group also fared worse than those in the combined modality (CM), LOH group, although the differences were not statistically significant in these smaller subgroups: 5 year relapse-free survival {23% (95% CI: 2% to 44%) vs. 54% (95% CI: 26% to 82%); p = 0.18}, locoregional control {34% (95% CI: 11% to 57%) vs. 61% (95% CI: 34% to 88%); p = 0.25} and cause specific survival {29% (95% CI: 5% to 53%) vs. 59% (95% CI: 30% to 88%); p = 0.12}.
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