Words similar to lhon

Example sentences for: lhon

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The two common pathogenic mutations in ND6 (Met64 → Val and Ala72 → Val) lead to a less severe and a very severe form of LHON, respectively [ 12].
The common missense substitution in ND1 that leads to LHON, Ala52 → Thr, does not have as obvious an explanation for its effect.
Further structural study of complex I will be required to explain how this mutation contributes to LHON.
As already described for LHON, Leigh syndrome and HSP, the causative mutations are not necessarily confined to a single protein-coding gene, or even to the nuclear versus the mitochondrial genome.
Leber's hereditary optic neuropathy (LHON), the most common cause of male adolescent blindness, is attributed to mutations in mtDNA genes encoding subunits of complex I (NADH dehydrogenase (ND) - alternatively termed NADH CoQ 1 reductase).