Words similar to lhon

Example sentences for: lhon

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The common missense substitution in ND1 that leads to LHON, Ala52 → Thr, does not have as obvious an explanation for its effect.
As already described for LHON, Leigh syndrome and HSP, the causative mutations are not necessarily confined to a single protein-coding gene, or even to the nuclear versus the mitochondrial genome.
The two common pathogenic mutations in ND6 (Met64 → Val and Ala72 → Val) lead to a less severe and a very severe form of LHON, respectively [ 12].
Leber's hereditary optic neuropathy (LHON), the most common cause of male adolescent blindness, is attributed to mutations in mtDNA genes encoding subunits of complex I (NADH dehydrogenase (ND) - alternatively termed NADH CoQ 1 reductase).
Further structural study of complex I will be required to explain how this mutation contributes to LHON.