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Example sentences for: lfa-

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LFA-1 - Lymphocyte Function associated Antigen.
On murine T cells and thymocytes, CD81 costimulates T cell receptor-mediated activation, through a pathway independent of CD28 [ 16 ] . On human T cells, CD81 costimulation results in increased IL-2 production and LFA-1-mediated T-B cell adhesion [ 17 ] . Murine CD81 also appears to play a role in thymocyte maturation as shown in fetal thymic organ cultures [ 18 ] .
However, in the current study, anti-LFA-1 was found to only partially block cytokine production induced by either SEB or SEB+anti-CD81 (data not shown).
showed that the enhancing effect of CD81 on SEB-induced activation was inhibited by antibody to LFA-1 [ 17 ] . The current results are consistent with the model proposed by VanCompernolle et al.
, whereby CD81 ligation induces an increase in LFA-1 avidity for ICAM-3 on accessory cells, resulting in an indirect activation effect on the T cells.