Words similar to leukotriene
Example sentences for: leukotriene
How can you use “leukotriene” in a sentence? Here are some example sentences to help you improve your vocabulary:
Alveolar macrophages have been shown to release TNF-α, prostaglandin E 2 , and leukotriene B 4 upon interaction with P. carinii [ 8].
Another example of co-receptors with multiple functions is the leukotriene family member B4, which was down-regulated in Tat expressing cells (Acc# D89078, Table 1).
In this regard, recent studies have shown that inflammatory mediators such as lipopolysaccharide (LPS), granulocyte macrophage-colony stimulating factor and leukotriene B 4 delay apoptosis and prolong neutrophil survival in culture [ 3 4 ] . Neutrophils migrating into rodent lungs in response to LPS challenge have also been reported to exhibit delayed rates of apoptosis [ 5 6 ] . Similarly, increases in cytokine and growth factor activity, and reduced neutrophil apoptosis, have been described in various inflammatory lung diseases in humans including chronic obstructive pulmonary disease, acute respiratory distress syndrome and pneumonia [ 3 7 8 ] .
The cysteinyl leukotrienes (CysLT), LTC, LTD, and LTE, were first shown to be essential mediators in asthma [ 29 ] . However, when the mouse leukotriene B4 receptor (m-BLTR) gene, was cloned it was shown to have significant sequence homology with chemokine receptors (CCR5 and CXCR4), co-receptors for many different HIV-1 clades [ 30 ] . Along the same lines, when cells were infected with 10 primary clinical isolates of HIV-1, leukotriene B4 receptor was primarily utilized for efficient entry into cells which were mainly of the syncytium-inducing phenotype [ 31 ] . Therefore, up-regulation of neuropeptide Y-like receptor and down-regulation of leukotriene B4 receptor in Tat expressing cells indicates a selective advantage of one class of virus (CCR5) over another (CXCR4).
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