Words similar to leptin-deficient
Example sentences for: leptin-deficient
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Furthermore, the effect of adrenalectomy on hypothalamic POMC mRNA may also depend genetic background [ 6 26 27 ] . Nevertheless, we hypothesized that if adrenalectomy enhanced hypothalamic POMC mRNA in diet-induced obesity in mice, as in leptin-deficient mice, adrenalectomy would also reverse obese phenotypes in mice that became obese due to a high-fat diet.
On the other hand, using the same adrenalectomy protocol that produced a similar reduction, but not elimination, of plasma corticosterone levels, we observed a remarkable reversal of obese phenotypes in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the reduction of corticosterone by adrenalectomy in the present study was sufficient to produce elevation of pituitary POMC mRNA (as well as hypothalamic POMC mRNA), demonstrating that the reduced levels were clearly producing physiological effects.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
As observed in leptin-deficient ob/ob mice, adrenalectomy in diet-induced obese mice led to a striking increase in hypothalamic POMC mRNA (Fig.
These data suggest that in fasting and insulin-deficient diabetes, as in leptin-deficient ob/ob mice [ 9 19 ] , glucocorticoids dominate leptin and insulin levels in determining AGRP expression, whereas insulin and leptin dominate glucocorticoids in determining hypothalamic POMC expression.
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