Example sentences for: leptin

How can you use “leptin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Five micrograms of total RNA from hypothalamus was subjected to Northern blot analysis, as described previously, to measure POMC, AGRP and NPY mRNA [ 3 4 5 9 ] . Seven micrograms of total RNA from adipose tissue was also subjected to Northern blot analysis to measure leptin mRNA.

  • Figure 3A shows the mean leptin levels for half-hour increments of average nightly sleep after adjustment for age, sex, BMI, and time of storage (see Table 2).

  • These data are also consistent with the observation that in streptozotocin-induced diabetic rats, replacement of insulin is not sufficient to normalize elevated serum corticosterone or the elevated hypothalamic AGRP mRNA while it does partially normalize plasma leptin and hypothalamic POMC mRNA [ 17 ] .

  • Since fasting, insulin deficiency, and leptin insufficiency also lead to an elevation in plasma glucocorticoids [ 8 ] , and adrenalectomy of leptin-deficient ob/ob mice largely normalizes hypothalamic gene expression in these mice [ 9 ] , it is plausible that elevated glucocorticoids may mediate some effects of nutritional state on hypothalamic gene expression.

  • However, obese people given injections of the hormone leptin in a study lost weight proportionate to dosage and lost fat cells only (25 percent of weight loss from diet and exercise is bone and muscle).


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