Example sentences for: leptin

How can you use “leptin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Short sleep duration was associated with decreased leptin and increased ghrelin, changes that have also been observed in reaction to food restriction and weight loss and are typically associated with increased appetite.

  • 1A) and reduced insulin and leptin (Fig.

  • [ 14 ] . These data suggest that leptin's effect to reverse effects of fasting on melanocortin tone may require and be mediated by a reduction in glucocorticoids.

  • Reduction in hypothalamic melanocortin tone, caused by reduction in proopiomelanocortin (POMC) mRNA and elevation in agouti-related peptide (AGRP) mRNA, is thought to play a key role in mediating nutritional effects on neuroendocrine function [ 1 2 ] . Thus fasting [ 3 4 ] , insulin deficiency [ 5 ] , and leptin deficiency [ 4 ] are all associated with reduced hypothalamic melanocortin tone.

  • On the other hand, leptin inhibits hypothalamic AGRP mRNA [ 4 ] , yet AGRP mRNA was nevertheless elevated in the face of elevated insulin and leptin.


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