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Example sentences for: lef-

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Several other HMG-box proteins also play important roles in lymphocyte development [ 17 ] . Mice doubly deficient in lymphocyte enhancement factor-1 (LEF-1) and T cell factor-1 (TCF-1) have a complete block in development of T cells [ 18 19 ] , while deficiency of SRY-box containing protein 4 (SOX-4) in mice results in a lack of pro-B cell expansion and mild perturbation of thymocyte development [ 20 ] . Unlike these HMG-box proteins, however, we find that the HMG-box of TOX is more closely related to the DNA binding domain of sequence-independent HMG-box proteins.
Human SRY, murine SOX-4, SOX-17, and LEF-1 contain single HMG-box motifs and bind DNA in a sequence-specific fashion.
The following plasmids were used in each experiment: 0.1 μg LEF-luciferase reporter [ 19 ] , 0.2 μg mouse LEF-1 and 0.1 μg Renilla luciferase.
The asparagine at position 10 makes contact with DNA in the hSRY-DNA complex [ 24 ] , as does the serine at this position in the NHP6A-DNA complex [ 7 ] . A hydrophobic residue at position 32 that can partially intercalate into DNA plays a role in DNA binding of some sequence-independent HMG-box proteins [ 7 25 26 ] . Position 32 is the hydrophobic residue phenylalanine in TOX, in contrast to the polar residues found at this position in SRY, SOX proteins and LEF-1.
1), LOC244579 mRNA (XM_146430), SOX-4 protein (NP_033264), SOX-17 protein (NP_035571), LEF-1 protein NP_034833), HMGB1 protein (CAA56631), upstream binding factor 1 (UBF-1) protein (NP_035681).