Words similar to lef

Example sentences for: lef

How can you use “lef” in a sentence? Here are some example sentences to help you improve your vocabulary:

However, they are consistent with the prevailing model in which Wg forms a trimeric complex with Arr and DFz2 that transduces a signal through Dsh to activate LEF/TCF-responsive promoters.
This developmentally important pathway contains several proteins, including APC, Frizzled, Axin and GSK3, which act in concert to promote the proteosomal degradation of β-catenin [ 13 14 ] . When APC is rendered inactive by mutation, β-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .
Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ] . Many downstream gene targets of the canonical Wnt/beta-catenin pathway have been identified http://www.stke.org.
Pathway activity was then assessed by measurement of luciferase expressed from a co-transfected plasmid containing firefly luciferase-coding sequence under the control of LEF binding elements.
Consequently, the level of cytoplasmic β-catenin rises, and stabilized β-catenin, together with the transcriptional factor LEF/TCF, regulates the transcription of Wnt target genes.