Example sentences for: latency-associated

How can you use “latency-associated” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • After binding to α V β 6 integrin, latent TGFβ 1 is activated by processing of latent TGFβ 1 by cleavage of the latency-associated Peptide (LAP) [ 45 46 47 48 49 50 51 52 53 54 55 56 57 ] . Recently, the interaction of latent TGFβ 1 with α V β 6 integrin has been shown [ 45 ] . After binding of latent TGFβ 1 to α V β 6 integrin, latent TGFβ 1 is activated by cleavage of the latency-associated peptide (LAP) [ 45 ] . This α V β 6 integrin is also expressed by pancreatic carcinoma cells [ 58 59 60 61 62 63 ] . We hypothesized that there is a SMAD-independent TGFβ 1 signaling pathway in TGFβ 1 -sensitive carcinoma cells.

  • This small latent complex may be secreted inefficiently from the cell surface at relatively slow rates [ 23 ] . However, when the small latent complex is bound by the latent transforming growth factor β-binding protein via a disulfide bond to the latency-associated peptide, the result is the formation of a large latent complex which may be secreted efficiently and at a relatively high rate compared to the small latent complex [ 23 ] . Latent TGF-β is then released from the extracellular matrix via proteolytic cleavage from the large latent complex, and the resulting active TGF-β is now able to bind to the appropriate TGF-β cell-surface receptors [ 24 ] .

  • During cellular synthesis of TGF-β, a small latent complex containing the latency-associated peptide and the mature TGF-β is synthesized.


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