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Example sentences for: laglidadg
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Structural comparisons using the DALI program [ 20], indicated that the core fold shared by the KilA-N and APSES domains is more distantly related to the LAGLIDADG site-specific DNA endonucleases and the amino-terminal domain of the tRNA splicing endonucleases (TEN domain) (Figure 1b) [ 21].
The KilA-N, APSES and TEN-terminal domains lack the equivalent residues of the specific active-site extension of the LAGLIDADG nucleases, suggesting that the former domains do not possess nuclease activity.
We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.
The potential higher-order structural relationship between the APSES and KilA-N domains with the LAGLIDADG site-specific DNA endonucleases and tRNA endonuclease amino-terminal domains has interesting implications for their evolutionary affinities and origin.
Additionally, the 3DPSSM threading also suggested that the LAGLIDADG endonuclease domain [ 18] (E-value 0.2; approximately 80% certainty) shared a common fold with the KilA-N proteins.