Words similar to laglidadg

Example sentences for: laglidadg

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A search with the APSES domain (PDB 1bm8) using the VAST program [ 22] detected significant structural alignments with both the LAGLIDADG and the TEN domains ( p approximately 10 -4).
The structural similarity between the TEN domain and LAGLIDADG nuclease domain has been previously noted [ 23], but the connection of both of these with the APSES domains has not been reported before to our knowledge.
Like the KilA-N domains that are mainly associated with DNA viruses, the LAGLIDADG endonucleases are predominantly encoded by mobile genetic elements [ 31].
We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.
The potential higher-order structural relationship between the APSES and KilA-N domains with the LAGLIDADG site-specific DNA endonucleases and tRNA endonuclease amino-terminal domains has interesting implications for their evolutionary affinities and origin.