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Example sentences for: laglidadg

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A structural comparison of these proteins indicates that the nuclease active site of the LAGLIDADG domains is contained in a specific amino-terminal α-helical extension packed against the core (β 2 α) 2 domain common to all these proteins (Figure 1b) [ 30].
The potential higher-order structural relationship between the APSES and KilA-N domains with the LAGLIDADG site-specific DNA endonucleases and tRNA endonuclease amino-terminal domains has interesting implications for their evolutionary affinities and origin.
The structural similarity between the TEN domain and LAGLIDADG nuclease domain has been previously noted [ 23], but the connection of both of these with the APSES domains has not been reported before to our knowledge.
A direct comparison of the structures also showed that the only domains that share a similar topology and conformation with the APSES domain are the LAGLIDADG and TEN domains.
We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.