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Example sentences for: laglidadg

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A search with the APSES domain (PDB 1bm8) using the VAST program [ 22] detected significant structural alignments with both the LAGLIDADG and the TEN domains ( p approximately 10 -4).
A structural comparison of these proteins indicates that the nuclease active site of the LAGLIDADG domains is contained in a specific amino-terminal α-helical extension packed against the core (β 2 α) 2 domain common to all these proteins (Figure 1b) [ 30].
Structural comparisons using the DALI program [ 20], indicated that the core fold shared by the KilA-N and APSES domains is more distantly related to the LAGLIDADG site-specific DNA endonucleases and the amino-terminal domain of the tRNA splicing endonucleases (TEN domain) (Figure 1b) [ 21].
We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.
A direct comparison of the structures also showed that the only domains that share a similar topology and conformation with the APSES domain are the LAGLIDADG and TEN domains.