Example sentences for: laglidadg

How can you use “laglidadg” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Structural comparisons using the DALI program [ 20], indicated that the core fold shared by the KilA-N and APSES domains is more distantly related to the LAGLIDADG site-specific DNA endonucleases and the amino-terminal domain of the tRNA splicing endonucleases (TEN domain) (Figure 1b) [ 21].

  • The KilA-N, APSES and TEN-terminal domains lack the equivalent residues of the specific active-site extension of the LAGLIDADG nucleases, suggesting that the former domains do not possess nuclease activity.

  • We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.

  • The potential higher-order structural relationship between the APSES and KilA-N domains with the LAGLIDADG site-specific DNA endonucleases and tRNA endonuclease amino-terminal domains has interesting implications for their evolutionary affinities and origin.

  • Additionally, the 3DPSSM threading also suggested that the LAGLIDADG endonuclease domain [ 18] (E-value 0.2; approximately 80% certainty) shared a common fold with the KilA-N proteins.


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