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Example sentences for: laglidadg

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Like the KilA-N domains that are mainly associated with DNA viruses, the LAGLIDADG endonucleases are predominantly encoded by mobile genetic elements [ 31].
A structural comparison of these proteins indicates that the nuclease active site of the LAGLIDADG domains is contained in a specific amino-terminal α-helical extension packed against the core (β 2 α) 2 domain common to all these proteins (Figure 1b) [ 30].
We noticed, however, that, although the TEN domain is related to the LAGLIDADG endonucleases, the active-site residues are not preserved in the former, and the TEN domain probably functions as a RNA-binding domain rather than a nuclease.
At least the former, and perhaps even the latter, appear to belong to a large class of nucleic-acid-binding domains that includes the APSES, LAGLIDADG endonuclease and TEN domains.
A search with the APSES domain (PDB 1bm8) using the VAST program [ 22] detected significant structural alignments with both the LAGLIDADG and the TEN domains ( p approximately 10 -4).