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Example sentences for: kur
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The K +channel subunits and currents modulated by estradiol in vascular and uterine smooth muscle differ from the 4-AP sensitive KCNA family channels that contribute to the 4-AP sensitive current I Kur in pig GC [ 4 49 50 52 53 ] . Moreover, in the single study where estradiol was shown to influence the gating of a uterine delayed rectifier current with electrophysiological characteristics resembling those of GC I Kur , the observed effect of the hormone was inhibitory [ 51 ] , and thereby similar rather than opposite to the effect of 4-AP.
Data obtained previously in our laboratory suggest that inhibition of granulosa I Kur should be associated with a +10 to +20 mV depolarization of cell resting membrane potential; block of I Ks alone decreased resting potential by +10 mV while block of both I Ks and I Kur decreased resting potential by +20 to +30 mV [ 18 ] . Most previous investigations of 4-AP effects on the resting membrane potentials of non-nerve, non-muscle cells have similarly demonstrated drug-induced depolarization [ 42 60 ] , although there is a single report showing 4-AP-induced hyperpolarization of chondrocyte membrane potential [ 62 ] .
4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.
Drug block of the voltage-gated potassium channels that conduct the ultra-rapid delayed rectifier current I Kur is associated with increased intracellular potassium concentration, increased cell volume, activation of chloride influx and hyperpolarization of resting membrane potential.
The data demonstrate that PGC-2 cells express K +currents similar to the granulosa cell ultra-rapid delayed rectifier current (I Kur ) in terms of the voltage-dependence and kinetics of activation and deactivation, as well as the sensitivity to 4-AP.
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