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Example sentences for: kur
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The K +channel subunits and currents modulated by estradiol in vascular and uterine smooth muscle differ from the 4-AP sensitive KCNA family channels that contribute to the 4-AP sensitive current I Kur in pig GC [ 4 49 50 52 53 ] . Moreover, in the single study where estradiol was shown to influence the gating of a uterine delayed rectifier current with electrophysiological characteristics resembling those of GC I Kur , the observed effect of the hormone was inhibitory [ 51 ] , and thereby similar rather than opposite to the effect of 4-AP.
The data demonstrate that PGC-2 cells express K +currents similar to the granulosa cell ultra-rapid delayed rectifier current (I Kur ) in terms of the voltage-dependence and kinetics of activation and deactivation, as well as the sensitivity to 4-AP.
4-aminopyridine, at millimolar concentrations, completely inhibits K +currents conducted by heterologously expressed KCNA channels and native GC I Kur , but lacks significant effects on native GC I Ks [ 4 12 13 20 ] . Kusaka showed that antagonism of 4-AP sensitive slowly inactivating delayed rectifier K +currents suppressed both basal and luteinizing hormone (LH)-stimulated progesterone production [ 21 ] . In this report, we extend those findings by demonstrating 4-AP inhibition of follicle stimulating hormone (FSH)-stimulated progesterone production, and by elucidating the underlying mechanisms.
Drug block of the voltage-gated potassium channels that conduct the ultra-rapid delayed rectifier current I Kur is associated with increased intracellular potassium concentration, increased cell volume, activation of chloride influx and hyperpolarization of resting membrane potential.
Data obtained previously in our laboratory suggest that inhibition of granulosa I Kur should be associated with a +10 to +20 mV depolarization of cell resting membrane potential; block of I Ks alone decreased resting potential by +10 mV while block of both I Ks and I Kur decreased resting potential by +20 to +30 mV [ 18 ] . Most previous investigations of 4-AP effects on the resting membrane potentials of non-nerve, non-muscle cells have similarly demonstrated drug-induced depolarization [ 42 60 ] , although there is a single report showing 4-AP-induced hyperpolarization of chondrocyte membrane potential [ 62 ] .
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