Words similar to krc
Example sentences for: krc
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KRC and tramtrack (TTK) share the same class of C 2 H 2 zinc finger pairs.
Since the RSS heptamer is a palindrome, it is possible for two KRC molecules to bind to an RSS heptamer, with one ZAS-C binding to the top strand and the other ZAS-C binding to the bottom strand.
Although previous results of protein titration experiments suggested that KRC/ZAS-C binds DNA in a cooperative manner for a given oligonucleotide, the presence of multiple binding sites might not be favored over a single site in our site selection assay which used a degenerate pool of oligonucleotides and limited rounds of amplification.
These data suggest that with respect to the RSS canonical elements, KRC/ZAS-N binds the nonamer more efficiently while KRC/ZAS-C binds the heptamer more efficiently, and that two KRC molecules may be needed to bind a single RSS element.
For example, the KRC/ZAS-C consensus sequence "ATTTTGTGG" matches completely with 6 nucleotides of the RSS nonamer and 3 flanking nucleotides of the human IgH D1, D2, D3 and D4 gene segments [ 35 ] . Furthermore, the MAST search identified KRC-selected motifs near two chromosomal breakpoints: between a t(11:14) translocation of the Ig DH2-2 gene segment and the B cell lymphoma 1 ( BCL-1 ) gene in a mantle cell lymphoma [ 36 ] , and at a t(11:19) translocation of the myeloid lymphoid leukemia ( MLL ) gene and the ENL/MLLT1/LTG19 gene in a T-cell acute lymphoblastic leukemia [ 37 ] . The other hits were derived from loci of cellular genes, pseduogenes, or DNA fragments [ 41 42 43 44 ] . The expression of those genes has not been shown to be regulated by KRC or other family members, therefore, the biological significance of those MAST results is unknown.
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