Example sentences for: kinases

How can you use “kinases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This census of protein kinases in the human genome provides a tool and framework for further investigation of this important gene family.

  • Several groups of Arabidopsis mutants that are resistant to the inhibitory effects of high sugar concentrations have been isolated [ 46 47 48 49 50 ] . Characterization of these mutants reveals that the sis5 [ 46 ] , sun6 [ 50 ] , gin6 [ 49 ] and isi3 [ 45 ] mutants are allelic to the abscisic acid insensitive mutant abi4 [ 51 ] and the sis4 [ 46 ] , isi4 [ 45 ] and gin1 [ 45 ] mutants are allelic to the abscisic acid biosynthesis mutant aba2 [ 52 ] . In addition, the ethylene constitutive response mutant ctr1-1 [ 53 ] , as well as the ethylene-overproduction mutant eto1 [ 54 ] , display sugar-resistant phenotypes [ 48 ] . Conversely, the sugar-response mutant sis1 exhibits an ethylene constitutive response phenotype and is allelic to ctr1-1 [ 47 ] . The prl1 mutant, which exhibits increased sensitivity to exogenous sugars [ 55 56 ] , carries a mutation in a gene that encodes a WD protein that interacts with SNF1 protein kinases [ 57 ] .

  • It is also of note that we can reproducibly co-immunoprecipitate Rlk and Fyn, perhaps due to their association with RAFTs, whereas we have been unable to co-precipitate Itk with Src family kinases when co-expressed in 293T cells (data not shown), again demonstrating distinct properties of the Rlk protein compared to certain other members of the Btk family.

  • Cdc37, like its higher eukaryotic homologs, promotes the physical integrity of multiple protein kinases, perhaps by virtue of a cotranslational role in protein folding [ 80 ] . Finally, Hsp90/Cdc37 has recently been shown in the stabilization/folding of Cdk9 as well as the assembly of an active Cdk9/cyclin T1 complex responsible for P-TEFb-mediated Tat transactivation [ 81 ] .

  • PP2 is a serine/threonine phosphatase which dephosphorylates JNK during inflammatory cell signaling [ 19 ] , while MKP5 is a member of the dual specificity phosphatase family which selectively dephosphorylates stress activated MAP kinases including JNK [ 20 ] . The overexpression of these two phosphatases might contribute in part to the resistance of HL60/TLK286 by impairing the activity of JNK.


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