Words similar to kinases
Example sentences for: kinases
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A characteristic phenotype of tumorigenic cells is their ability to grow anchorage-independently in suspension culture, or embedded in soft agar, without the need for attachment to the surface of a cell culture dish [ 25 26 ] . A flurry of papers has established a close link between anchorage-independent growth and the activity of several components of the cell cycle machinery, such as various cyclins, cyclin-dependent kinases (CDKs), and the CDK inhibitors p21 Cip1and p27 Kip1 [ 27 28 29 30 31 32 ] . There are indications that PTEN may be involved in these processes as well.
At least eight potential serine and threonine phosphorylation sites are present in the human protein involving such kinases as casein kinase I and II, protein kinase A and C, glycogen synthase kinase 3 and calmodulin-dependent protein kinase II (Figure 2).
Our mutational analysis of Rlk supports a similar mechanism for activation of Rlk by Src family kinases downstream of the TCR.
These genes represent important targets of flavopiridol action as they encode M-phase regulatory kinases (PLK, aurora/IPL1-related kinase, and ckshs2), M-phase checkpoint proteins (CHK1), and chromosome segregation proteins (CENP-E, CENP-F) (Figure 4a).
These include p150 RhoA-binding kinase α and β (p150 ROKα and β) [ 40 41 ] , p160 Rho-associated coiled-coil containing protein kinase (Rho-p160ROCK) [ 42 ] , p164 Rho kinase [ 43 ] , p120 protein kinase N (p120 PKN) [ 44 45 ] , and PKC-related kinase-2 (PRK-2) [ 46 ] . These kinases specifically bind to the GTP bound form of Rho, except for PRK-2, which can bind both Rho and Rac GTPases.
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