Words similar to kinases
Example sentences for: kinases
How can you use “kinases” in a sentence? Here are some example sentences to help you improve your vocabulary:
It has been postulated that activation of these kinases allows GPCR agonists to modulate such diverse molecular events as cell proliferation, differentiation, and survival [ 1 ] . To date, all three cloned opioid receptor types (μ,δ, κ) and the closely related nociceptin receptor have demonstrated the ability to signal through their heterotrimeric G proteins (G i or G o ) to at least one type of MAPK [ 2 3 4 ] . Among the members of this family that are activated by opioids, are the two extracellular signal-regulated protein kinases (p44 MAPK(ERK 1) and p42 MAPK(ERK 2)) [ 5 ] and the p38 protein kinase [ 3 ] . However, the precise mechanism by which OR stimulation produces an increase in MAPK activity is still unknown and under investigation.
This census of protein kinases in the human genome provides a tool and framework for further investigation of this important gene family.
Both of these types of receptor signaling pathways have recently been shown to interact with serine/threonine kinases such as MAP kinases.
During this transition, tightly-regulated post-translational phosphorylation-dephosphorylation events and proteasome-mediated proteolytic reactions regulate the activation and inactivation of signal transduction pathways that control chromatin condensation, nuclear membrane dissolution, microtubule nucleation, and formation of a haploid oocyte [ 8 9 10 ] . Several kinases that exert major roles during OM include maturation promoting factor (MPF) [ 9 11 ] , mitogen-activated protein kinases (MAPKs) [ 12 13 ] , and the product of the c-mos protooncogene Mos kinase [ 14 15 ] . Also, during OM oocytes undergo two highly-regulated metaphase-anaphase transitions (MAT) in which homologous chromosomes are equally and randomly segregated to an oocyte and first polar body and a subsequent division in which equational division of sister chromatids results in a haploid oocyte and a second polar body.
This second class of adaptor proteins is characterized by a substrate domain with multiple tyrosines for phosphorylation by upstream kinases.
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