Example sentences for: kinase-defective

How can you use “kinase-defective” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To confirm that the kinase-defective receptors were functioning in a dominant-negative fashion, we studied the ability of CHO and CHO-MK cells to incorporate 3H-thymidine into DNA in response to IGF-I stimulation.

  • Cells transfected with the kinase-defective IGF-IR showed a more benign morphology with no invasion of the capsule (Panel C and data not shown).

  • Overexpression of the wild-type IGF-IRs increased the number of colonies, and overexpressing the kinase-defective receptors reduced the number of colonies by 60% (Figure 1C).

  • To make expression of kinase defective IGF-I receptors in different cell lines more tractable, we generated pseudotyped retroviruses expressing either the kinase-defective (MK) or wild-type (WT) IGF-I receptors.

  • Very few apoptotic cells are seen in the CHO parental and CHO-WT cells, whereas apoptotic cells are seen throughout the tumor from the kinase-defective CHO-MK cells.


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