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Example sentences for: kappen

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A similar phenotype is found in Hoxd-4 transgenic mice ( [ 1 ] and Kappen, manuscript in preparation) indicating that Hox transcription factors regulate chondrocyte development.
We found a similar phenotype upon overexpression of Hoxd-4 in our transgenic system (Kappen, manuscript in preparation), whereas overexpression of the LIM-homeodomain transcription factor Isl-1 did not cause abnormalities in cartilage but other developmental defects [ 1 9 ] . The observation that cartilage is affected by misregulation of Hoxc-8 and Hoxd-4, but not by a divergent homeobox gene, indicates that the capacity to regulate cartilage differentiation is specific to homeobox genes of the Hox subclass.
There is little evidence to support this possibility as Hoxc-8 is expressed normally in our chondrocyte cultures (data not shown), and the promoter used to drive the transgene contains a cartilage-specific element (Cormier and Kappen, unpublished results) that is active in chondrocytes.