Words similar to kaposi
Example sentences for: kaposi
How can you use “kaposi” in a sentence? Here are some example sentences to help you improve your vocabulary:
Blacks with HIV infection have a lower risk of cancer developing than nonblacks [ 22 ] . Kaposi sarcoma and non-Hodgkin lymphoma are the most common malignancies, and they are epidemiologically linked to HIV.
Kaposi sarcoma has been reported in all HIV risk groups.
For example, viral IL-6 might be incorporated into the genomes of prostatic carcinomas, as has been described for Kaposi sarcoma [ 5 32 33 39 40 41 ] . The route of introduction of the viral IL-6 is believed to be through previous herpesvirus infection [ 39 41 ] . Another possibility is that the insertion of the oncogene BRCA1 results in the constitutive activation of STAT3 in NRP-154 cells, as has been described in Du-145 prostate cancer cells [ 42 ] . Du-145 cells do not make IL-6; nor are they dependent upon it for continued proliferation in vitro.
Enhancement of IL-6 production by dexamethasone treatment has been previously observed in Kaposi's sarcoma cells [ 32 ] . In the case of NRP-154 cells, the steroid-responsive element for dexamethasone on the IL-6 promoter may have been mutated to a form that does not bind steroid receptors.
For example, early investigators observed that transfection of untransformed B cells with a plasmid for constitutive expression of IL-6 conferred the tumorigenic phenotype on the cells [ 2 ] . IL-6 is a key factor in myeloma progression and survival [ 3 4 ] , and also in Kaposi's sarcoma, a solid tumor [ 5 ] . In myeloma, the standard therapy for treatment includes prednisone, which acts by inhibiting IL-6 synthesis.
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