Words similar to kaposi
Example sentences for: kaposi
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Kaposi sarcoma has been reported in all HIV risk groups.
Mutations in the IL-6 promoter region may play a role in the tumorigenic effects of constitutive IL-6 expression in prostatic carcinoma cells [ 33 ] . Such polymorphisms have been described for the IL-6 receptor in Kaposi's sarcoma, and are believed to play a role in IL-6-mediated progression of this type of cancer [ 32 ] .
For example, viral IL-6 might be incorporated into the genomes of prostatic carcinomas, as has been described for Kaposi sarcoma [ 5 32 33 39 40 41 ] . The route of introduction of the viral IL-6 is believed to be through previous herpesvirus infection [ 39 41 ] . Another possibility is that the insertion of the oncogene BRCA1 results in the constitutive activation of STAT3 in NRP-154 cells, as has been described in Du-145 prostate cancer cells [ 42 ] . Du-145 cells do not make IL-6; nor are they dependent upon it for continued proliferation in vitro.
Enhancement of IL-6 production by dexamethasone treatment has been previously observed in Kaposi's sarcoma cells [ 32 ] . In the case of NRP-154 cells, the steroid-responsive element for dexamethasone on the IL-6 promoter may have been mutated to a form that does not bind steroid receptors.
Blacks with HIV infection have a lower risk of cancer developing than nonblacks [ 22 ] . Kaposi sarcoma and non-Hodgkin lymphoma are the most common malignancies, and they are epidemiologically linked to HIV.