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Example sentences for: kaposi

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For example, early investigators observed that transfection of untransformed B cells with a plasmid for constitutive expression of IL-6 conferred the tumorigenic phenotype on the cells [ 2 ] . IL-6 is a key factor in myeloma progression and survival [ 3 4 ] , and also in Kaposi's sarcoma, a solid tumor [ 5 ] . In myeloma, the standard therapy for treatment includes prednisone, which acts by inhibiting IL-6 synthesis.
Enhancement of IL-6 production by dexamethasone treatment has been previously observed in Kaposi's sarcoma cells [ 32 ] . In the case of NRP-154 cells, the steroid-responsive element for dexamethasone on the IL-6 promoter may have been mutated to a form that does not bind steroid receptors.
However, it occurs predominantly in homosexual and bisexual men [ 23 ] . In the PIP study, homosexuality was not a predominant HIV risk factor, and pulmonary Kaposi sarcoma was diagnosed in only 1 patient.
Mutations in the IL-6 promoter region may play a role in the tumorigenic effects of constitutive IL-6 expression in prostatic carcinoma cells [ 33 ] . Such polymorphisms have been described for the IL-6 receptor in Kaposi's sarcoma, and are believed to play a role in IL-6-mediated progression of this type of cancer [ 32 ] .
Blacks with HIV infection have a lower risk of cancer developing than nonblacks [ 22 ] . Kaposi sarcoma and non-Hodgkin lymphoma are the most common malignancies, and they are epidemiologically linked to HIV.