Words similar to jra
Example sentences for: jra
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Among children with pauciarticular JRA, DEK autoantibodies were significantly more common in those with JRA-associated uveitis than in those without eye disease [ 8 9 ] . DEK reactivity was also found to be strongly associated with onset of any JRA subtype before age 6 years [ 8 ] .
Although juvenile rheumatoid arthritis (JRA) is the most common cause of disability in children, its etiology is unknown.
AS = ankylosing spondylitis; B27 = histocompatibility antigen B27; CREST = calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, telangiectasia; E 2 = estradiol-17β JRA = juvenile rheumatoid arthritis; RA = rheumatoid arthritis; RAD = rheumatic/autoimmune disease; SLE = systemic lupus erythematosus.
Immune dysregulation appears to play a key pathogenic role, as circulating autoantibodies are common in patients with certain JRA clinical subtypes [ 1 2 3 4 5 6 7 ] . Two recent studies have shown a highly significant association between early-onset pauciarticular JRA and circulating antibodies to the 43-kDa nuclear protein DEK [ 8 9 ] . Although circulating DEK antibodies have subsequently been found in children and adults with other autoimmune diseases [ 10 11 ] , these two studies did reveal that children with JRA are significantly more likely to have anti-DEK antibodies than are children without rheumatic disease.
Development of antibodies to DEK could even be a primary event in the pathogenesis of JRA, with disruption of nuclear events due to penetration of anti-DEK antibodies into living cells [ 35 ] . It remains to be determined whether anti-DEK antibodies are directly involved in the pathogenesis of autoimmune disease, or if they result from generally enhanced immunoreactivity.
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