Words similar to jra
Example sentences for: jra
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Among children with pauciarticular JRA, DEK autoantibodies were significantly more common in those with JRA-associated uveitis than in those without eye disease [ 8 9 ] . DEK reactivity was also found to be strongly associated with onset of any JRA subtype before age 6 years [ 8 ] .
The DQA1*0501 allele is strongly associated with early-onset pauciarticular JRA in Northern European populations [ 23 24 ] and with increased risk for juvenile dermatomyositis [ 25 ] and Sjögren's syndrome with high autoantibody production [ 26 27 ] . In our proposed model, aberrant class II MHC regulation could result from altered DEK binding and/or interaction with NF-Y, and aberrant class II expression may alter or enhance reactivity against DEK-derived or other self peptides.
Considering that the frequency of RAD in Mexico City, where our study was performed, is about 0.83% (including RA 0.62%; SLE 0.03%; polymyositis/dermatomyositis 0.04%; JRA 0.03%; AS 0.01%; and other RAD [Sjogren's syndrome, mix connective tissue disease, etc.], 0.1%) [ 32], the relatively large number of cases of RAD in this very small group of male patients with untreated hypogonadism was surprisingly high ( P < 0.001), suggesting a strong relation between the two conditions (see Supplementary Table 2).
Immune dysregulation appears to play a key pathogenic role, as circulating autoantibodies are common in patients with certain JRA clinical subtypes [ 1 2 3 4 5 6 7 ] . Two recent studies have shown a highly significant association between early-onset pauciarticular JRA and circulating antibodies to the 43-kDa nuclear protein DEK [ 8 9 ] . Although circulating DEK antibodies have subsequently been found in children and adults with other autoimmune diseases [ 10 11 ] , these two studies did reveal that children with JRA are significantly more likely to have anti-DEK antibodies than are children without rheumatic disease.
However, other patients with hypogonadism who also had JRA and AS had only a few articular symptoms, so slight that the RAD had gone unnoticed until we looked for it.
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