Words similar to iκbα

Example sentences for: iκbα

How can you use “iκbα” in a sentence? Here are some example sentences to help you improve your vocabulary:

Preliminary studies on TNF-induced IκBα phosphorylation determined the optimum concentration for inhibition with infliximab.
Hyal-2-increased TNF susceptibility in L929 cells appears to be associated with 1) Hyal-2 upregulation of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptotic cell death, and 3) the prolonged IκBα degradation and NF-κB activation in Hyal-2-expressing cells stimulated with TNF.
IκBα is a physiological inhibitor of NF-κB activation; IκBα complexes with NF-κB and prevents its translocation to the nucleus [ 10 24 ] . NF-κB activation is believed to induce antiapoptotic proteins to block cell death [ 8 ] . However, in several studies activated NF-κB cannot protect cells from apoptosis [ 8 ] . Also, NF-κB appears to be essential in the p53-mediated apoptosis in tested cell lines [ 25 ] .
It is unclear whether this extend ed period of IκBα degradation and NF-κB activation directly contributes to the ability of Hyal-2 to enhance TNF-mediated apoptosis.
However, there was an extended period of TNF-mediated IκBα degradation and NF-κB activation in Hyal-2 cells, ranging from 20-60 min.