Example sentences for: iκbα
How can you use “iκbα” in a sentence? Here are some example sentences to help you improve your vocabulary:
IκBα is a physiological inhibitor of NF-κB activation; IκBα complexes with NF-κB and prevents its translocation to the nucleus [ 10 24 ] . NF-κB activation is believed to induce antiapoptotic proteins to block cell death [ 8 ] . However, in several studies activated NF-κB cannot protect cells from apoptosis [ 8 ] . Also, NF-κB appears to be essential in the p53-mediated apoptosis in tested cell lines [ 25 ] .
Hyal-2-increased TNF susceptibility in L929 cells appears to be associated with 1) Hyal-2 upregulation of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptotic cell death, and 3) the prolonged IκBα degradation and NF-κB activation in Hyal-2-expressing cells stimulated with TNF.
IκBα degradation and NF-κB activation (or NF-κB nuclear translocation) were observed at 20 to 60 min in Hyal-2 cells post TNF stimulation, but at the 20 min time point in both control and Hyal-1 cells (Fig.
These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
Next, the effect of TNF-mediated IκBα degradation and NF-κB activation was examined in both Hyal-1 and Hyal-2 cells.
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