Example sentences for: iκbα
How can you use “iκbα” in a sentence? Here are some example sentences to help you improve your vocabulary:
However in that model IκBα, the inhibitor of the NF-kB complex was still degraded.
Preliminary studies on TNF-induced IκBα phosphorylation determined the optimum concentration for inhibition with infliximab.
These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
Antisera against WOX1 were generated in rabbits against a synthetic peptide [ 10 ] . Antibodies against p53, IκBα, NF-κB p65 and α-tubulin were from Santa Cruz Biotechnology (Santa Cruz, CA) and Accurate Chemicals (Accurate Chemical, Westbury, NY).
These preparations were subjected to SDS-PAGE and Western blotting using specific antibodies against IκBα, WOX1 and NF-κB.
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