Example sentences for: iκbα
How can you use “iκbα” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is unclear whether this extend ed period of IκBα degradation and NF-κB activation directly contributes to the ability of Hyal-2 to enhance TNF-mediated apoptosis.
These preparations were subjected to SDS-PAGE and Western blotting using specific antibodies against IκBα, WOX1 and NF-κB.
Hyal-2-increased TNF susceptibility in L929 cells appears to be associated with 1) Hyal-2 upregulation of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptotic cell death, and 3) the prolonged IκBα degradation and NF-κB activation in Hyal-2-expressing cells stimulated with TNF.
Antisera against WOX1 were generated in rabbits against a synthetic peptide [ 10 ] . Antibodies against p53, IκBα, NF-κB p65 and α-tubulin were from Santa Cruz Biotechnology (Santa Cruz, CA) and Accurate Chemicals (Accurate Chemical, Westbury, NY).
IκBα degradation and NF-κB activation (or NF-κB nuclear translocation) were observed at 20 to 60 min in Hyal-2 cells post TNF stimulation, but at the 20 min time point in both control and Hyal-1 cells (Fig.
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