Example sentences for: iκbα
How can you use “iκbα” in a sentence? Here are some example sentences to help you improve your vocabulary:
It is unclear whether this extend ed period of IκBα degradation and NF-κB activation directly contributes to the ability of Hyal-2 to enhance TNF-mediated apoptosis.
IκBα is a physiological inhibitor of NF-κB activation; IκBα complexes with NF-κB and prevents its translocation to the nucleus [ 10 24 ] . NF-κB activation is believed to induce antiapoptotic proteins to block cell death [ 8 ] . However, in several studies activated NF-κB cannot protect cells from apoptosis [ 8 ] . Also, NF-κB appears to be essential in the p53-mediated apoptosis in tested cell lines [ 25 ] .
However in that model IκBα, the inhibitor of the NF-kB complex was still degraded.
However, there was an extended period of TNF-mediated IκBα degradation and NF-κB activation in Hyal-2 cells, ranging from 20-60 min.
These preparations were subjected to SDS-PAGE and Western blotting using specific antibodies against IκBα, WOX1 and NF-κB.
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