Example sentences for: iκbα
How can you use “iκbα” in a sentence? Here are some example sentences to help you improve your vocabulary:
However in that model IκBα, the inhibitor of the NF-kB complex was still degraded.
IκBα is a physiological inhibitor of NF-κB activation; IκBα complexes with NF-κB and prevents its translocation to the nucleus [ 10 24 ] . NF-κB activation is believed to induce antiapoptotic proteins to block cell death [ 8 ] . However, in several studies activated NF-κB cannot protect cells from apoptosis [ 8 ] . Also, NF-κB appears to be essential in the p53-mediated apoptosis in tested cell lines [ 25 ] .
It is unclear whether this extend ed period of IκBα degradation and NF-κB activation directly contributes to the ability of Hyal-2 to enhance TNF-mediated apoptosis.
IκBα degradation and NF-κB activation (or NF-κB nuclear translocation) were observed at 20 to 60 min in Hyal-2 cells post TNF stimulation, but at the 20 min time point in both control and Hyal-1 cells (Fig.
Antisera against WOX1 were generated in rabbits against a synthetic peptide [ 10 ] . Antibodies against p53, IκBα, NF-κB p65 and α-tubulin were from Santa Cruz Biotechnology (Santa Cruz, CA) and Accurate Chemicals (Accurate Chemical, Westbury, NY).
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