Words similar to iκb

Example sentences for: iκb

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Both aspirin (via IκB kinase) and rosiglitazone (via PPARγ) inhibit NF-κB [31,32], which is activated by LPS.
NHBEs were treated with increasing concentrations of CSC and whole-cell extracts were immunoblotted for phosphorylated IκB.
We have recently described the role of Bcl-3, an IκB family member, in the signaling pathways of IL-1 leading to MMP-1 expression in SW-1353 cells and rabbit synovial fibroblasts [ 24 ] . We found that IL-1 could induce the expression of Bcl-3, and that Bcl-3 had a direct effect on MMP-1 expression through cooperation with NF-κB1/p50.
In that report, NO was found to induce IκB synthesis through activation of its promoter, therefore, increased IkB-a might also contribute to NF-kB inhibition . Several other possible pathways, e.g. p38, p42/44 MAPK and transcription factors, e.g.
The Toll-like receptor family [ 49], which has evolutionary roots throughout invertebrate metazoans for pattern-based recognition of bacterial and fungal cell-surface components [ 50], activate NFκB through convergent pathways involving the IL-1 receptor-associated kinase (IRAK), the adaptor protein MyD88, TRAF6, NFκB-inducing kinase (NIK), and IκB kinase (Iκk) [ 51].