Example sentences for: iκb
How can you use “iκb” in a sentence? Here are some example sentences to help you improve your vocabulary:
In that report, NO was found to induce IκB synthesis through activation of its promoter, therefore, increased IkB-a might also contribute to NF-kB inhibition . Several other possible pathways, e.g. p38, p42/44 MAPK and transcription factors, e.g.
We have recently reported the role of the inhibitor of NF-κB (IκB) family member Bcl-3 in IL-1-induced MMP-1 expression [ 24 ] . Here we show that overexpression of Bcl-3 can partly abrogate CDDO's inhibitory effects on MMP-1 in SW-1353 cells, suggesting that Bcl-3 might be a target for CDDO.
NHBEs exposed to CSC also showed an increase in nuclear staining of phosphorylated IκB as detected by immunocytochemical staining using an antibody to phosphorylated IκB (Fig.
The Toll-like receptor family [ 49], which has evolutionary roots throughout invertebrate metazoans for pattern-based recognition of bacterial and fungal cell-surface components [ 50], activate NFκB through convergent pathways involving the IL-1 receptor-associated kinase (IRAK), the adaptor protein MyD88, TRAF6, NFκB-inducing kinase (NIK), and IκB kinase (Iκk) [ 51].
Activation of NFκB involves the increased phosphorylation and proteolytic degradation of IκB.