Example sentences for: iκb
How can you use “iκb” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have recently described the role of Bcl-3, an IκB family member, in the signaling pathways of IL-1 leading to MMP-1 expression in SW-1353 cells and rabbit synovial fibroblasts [ 24 ] . We found that IL-1 could induce the expression of Bcl-3, and that Bcl-3 had a direct effect on MMP-1 expression through cooperation with NF-κB1/p50.
Exposure of cells to stimuli of NF-κB induces the rapid phosphorylation and subsequent degradation of IκB proteins.
In the same time-course experiment, we assayed for the presence of Bcl-3, an IκB family member that we have previously shown to have a role in MMP-1 expression.
Protein bands were quantitated by densitometry on the film and the phosphorylated IκB densities were normalized to the levels of IκB.
Anti-phosphorylated IκB-α polyclonal antibody, IκB monoclonal antibody and chemiluminescent detection reagents were from Cell Signaling Technology (Beverly, MA, USA).