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Example sentences for: ix

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This basic domain organization shows a striking parallel to that of magnesium chelatase, a heterotrimeric enzyme containing BchD, BchI and BchH subunits, that performs ATP-dependent insertion of Mg 2+into the protoporphyrin IX ring in the course of chlorophyll biosynthesis [ 49 ] . In particular, the BchD subunit resembles midasin in possessing a single AAA protomer close to its NH 2 -terminus, together with a short aspartate-glutamate-rich region and a MIDAS-containing domain at its carboxy-terminus.
Hyal-1 is a candidate tumor suppressor [ 5 18 ] , although it enhances extravasation and metastasis of prostate cancer cells [ 3 ] . Also, mutations in Hyal-1 may contribute to the pathogenesis of a lysosomal disorder, mucopolysaccharidosis IX [ 19 ] . Hyal-2 is a lysosomal protein, which is active at low pH [ 20 ] . This protein is also known to be a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus [ 21 ] .
The second platelet GP of interest is GPIbα, a transmembranous platelet GP (molecular weight, 143,000) that forms noncovalent complexes with GPIbβ, GPIX, and GPV to form the GPIb/IX/V receptor, which is involved in shear stress-induced platelet activation by binding to von Willebrand factor (vWF).
[p. ix]
Protoporphyrin IX, hemin, hematin, and nicotinamide (vitamin B 3 ) were purchased from Aldrich (Milwaukee, WI).