Words similar to irreversibly

Example sentences for: irreversibly

How can you use “irreversibly” in a sentence? Here are some example sentences to help you improve your vocabulary:

In the competition between proteolysis and deubiquitination, polyubiquitinated proteins rarely accumulate in the cytoplasm of “healthy” cells, as they are either irreversibly degraded or deubiquitinated and rescued.
sα i2 may exist in a state that does not interact well with βγ simply because it is in the process of being irreversibly inactivated [ 9 10 ] . Similarly, α i2 A327S appears not to be defective in its intrinsic ability to interact βγ [ 10 ] , and co-expression of βγ shifts α i2 A327S, like sα i2 , from intracellular to plasma membranes (Figure 8).
As shown in Figure 6C, fixation under the widely used conditions at room temperature (25°C) for 20 min, is not sufficient to irreversibly crosslink actin, moesin and many other polypeptides.
For this reason, it is preferable that microbicides irreversibly inactivate the virus upon the first compound/HIV-1 encounter in the vaginal environment, i.e. microbicides should have direct virucidal activity.
In a separate study, we have shown that Az and HsN3 play targeting roles in the proteasomal degradation of Smad1 upon the activation of BMP type I receptors [ 39 ] . The observed proteasomal degradation of Smad1 upon the activation of BMP signaling could simply serve to irreversibly terminate Smad1-mediated signaling pathways of BMPs.