Example sentences for: irreversibly

How can you use “irreversibly” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • In a separate study, we have shown that Az and HsN3 play targeting roles in the proteasomal degradation of Smad1 upon the activation of BMP type I receptors [ 39 ] . The observed proteasomal degradation of Smad1 upon the activation of BMP signaling could simply serve to irreversibly terminate Smad1-mediated signaling pathways of BMPs.

  • IFN-γ potently and irreversibly inhibits RANKL-induced osteoclastogenesis

  • Cells in mature animal tissues are not, as we had thought, irreversibly differentiated.

  • sα i2 may exist in a state that does not interact well with βγ simply because it is in the process of being irreversibly inactivated [ 9 10 ] . Similarly, α i2 A327S appears not to be defective in its intrinsic ability to interact βγ [ 10 ] , and co-expression of βγ shifts α i2 A327S, like sα i2 , from intracellular to plasma membranes (Figure 8).

  • In the competition between proteolysis and deubiquitination, polyubiquitinated proteins rarely accumulate in the cytoplasm of “healthy” cells, as they are either irreversibly degraded or deubiquitinated and rescued.


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