Words similar to irreversibly

Example sentences for: irreversibly

How can you use “irreversibly” in a sentence? Here are some example sentences to help you improve your vocabulary:

In a separate study, we have shown that Az and HsN3 play targeting roles in the proteasomal degradation of Smad1 upon the activation of BMP type I receptors [ 39 ] . The observed proteasomal degradation of Smad1 upon the activation of BMP signaling could simply serve to irreversibly terminate Smad1-mediated signaling pathways of BMPs.
Our studies provide first systematic data that cells should be kept in 4% PFA for at least 60 min at room temperature or for 20 min at 37°C to irreversibly crosslink most of the polypeptides (Figure 6).
Once bound to the proteasome, a polyubiquitinated substrate can be unfolded by the RP and irreversibly translocated into the CP.
For this reason, it is preferable that microbicides irreversibly inactivate the virus upon the first compound/HIV-1 encounter in the vaginal environment, i.e. microbicides should have direct virucidal activity.
As shown in Figure 6C, fixation under the widely used conditions at room temperature (25°C) for 20 min, is not sufficient to irreversibly crosslink actin, moesin and many other polypeptides.