Words similar to ipns
Example sentences for: ipns
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The conserved portion of the 2OG-Fe(II) dioxygenase superfamily proteins comprises the core DSBH domain seen in the IPNS, DAOCS and CAS structures [ 8, 9, 10] and part of the amino-terminal α helix that showed considerable variability in both length and sequence between individual families (Figures 1, 2).
Similarly, fungi contain several enzymes involved in secondary metabolite biosynthesis, such as IPNS and DAOCS, that are distinctly related to their counterparts in actinomycetes.
The roles of all these conserved residues in catalysis are apparent from the crystal structures of IPNS, clavaminic acid synthase (CAS) and deacetoxycephalosporin C synthase (DAOCS) [ 8, 9, 10].
For example, the insert between the fifth and sixth strand in AlkB is predicted to contain an extra strand, whereas in the small-molecule dioxygenase (IPNS/ethylene-forming enzyme (EFE)) family, the same region forms (or is predicted to form) a short helix (Figures 1, 3).
Whereas most of these enzymes necessarily use 2-OG as the acidic substrate, IPNS does not bind 2-OG.
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