Words similar to intima
Example sentences for: intima
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There was a significant increase of chemokine-positive cells in inflamed intima compared to noninflamed intima, for both RA and non-RA synovia.
These sites were evident around blood vessels of the subintima, throughout the subintimal stroma and in the intima.
The number of sections per patient was four, giving a total of 3360 μm of intima measured per patient.
The normal intima of the synovium is one to two cells thick and consists mainly of macrophage-like and fibroblast-like cells [ 3 ] . In inflammation, macrophages make a large contribution to intimal thickening, where these cells increase in number and proportion [ 3 ] . Evidence indicates that intimal macrophages arrive via the circulation as monocytes [ 4 ] , and it is proposed that increased numbers of intimal macrophages in RA are largely attributed to enhanced monocyte recruitment from blood vessels in the synovium [ 1 5 ] . Neutrophils are also recruited in RA and can be found in abundance in synovial fluid, yet they occur in relatively low numbers in the synovium [ 5 ] . In synovial fluid their number can reach 10 6per joint, particularly during an active phase of the disease [ 6 ] . Neutrophils occur at the pannus-cartilage junction [ 7 ] and it is presumed that these cells reach the joint cavity by migrating from the blood vessels in the synovium, following a chemotactic gradient.
In RA there is increased recruitment of monocytes, which migrate into the synovial subintima and to the intima, presumably following a chemotactic gradient [ 3 ] . The increase in synovial macrophage numbers is mainly due to enhanced recruitment since there appears to be little contribution from in situ proliferation of these cells [ 21 ] , although deficient apoptosis may have an effect on increasing cell number [ 1 ] . There is also increased recruitment of neutrophils in RA, migrating from subintimal venules, across the synovium and into the synovial fluid where they can occur in large numbers.
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