Words similar to intima
Example sentences for: intima
How can you use “intima” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, there were more cells binding CXCL8 in inflamed, non-RA intima compared to inflamed RA tissue.
In RA there is increased recruitment of monocytes, which migrate into the synovial subintima and to the intima, presumably following a chemotactic gradient [ 3 ] . The increase in synovial macrophage numbers is mainly due to enhanced recruitment since there appears to be little contribution from in situ proliferation of these cells [ 21 ] , although deficient apoptosis may have an effect on increasing cell number [ 1 ] . There is also increased recruitment of neutrophils in RA, migrating from subintimal venules, across the synovium and into the synovial fluid where they can occur in large numbers.
All four chemokines bound to synovial tissue cells in the subintima and the intima in every RA and non-RA individual (Supplementary Fig.
A higher percentage of cells, however, bound CXCL8 in non-RA inflamed intima compared to RA inflamed intima.
The normal intima of the synovium is one to two cells thick and consists mainly of macrophage-like and fibroblast-like cells [ 3 ] . In inflammation, macrophages make a large contribution to intimal thickening, where these cells increase in number and proportion [ 3 ] . Evidence indicates that intimal macrophages arrive via the circulation as monocytes [ 4 ] , and it is proposed that increased numbers of intimal macrophages in RA are largely attributed to enhanced monocyte recruitment from blood vessels in the synovium [ 1 5 ] . Neutrophils are also recruited in RA and can be found in abundance in synovial fluid, yet they occur in relatively low numbers in the synovium [ 5 ] . In synovial fluid their number can reach 10 6per joint, particularly during an active phase of the disease [ 6 ] . Neutrophils occur at the pannus-cartilage junction [ 7 ] and it is presumed that these cells reach the joint cavity by migrating from the blood vessels in the synovium, following a chemotactic gradient.
Loading...