Example sentences for: insulin-like

How can you use “insulin-like” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The data indicate that an insulin-like signaling pathway negatively regulates life span, as had previously been found for the nematode C. elegans [ 18].

  • et al . found significantly different baseline expression levels of insulin-like growth factor (IGF) and insulin-like growth factor binding protein (IGFBP) between normal and AIS-derived genital skin fibroblasts, and could not detect changes in transcript levels in response to androgen treatment [ 29 ] . In normal genital fibroblasts, androgen-responsive reporter genes can only be activated by expression of co-transfected AR in the presence of ligand [ 30 ] . Therefore, endogenous AR expression itself may be insufficient in genital skin fibroblasts to elicit a transcriptional response.

  • Inr is homologous to the mammalian insulin receptor and insulin-like growth factor receptor, while chico is homologous to the mammalian insulin receptor substrate.

  • The increased life span regulated by the insulin-like signaling pathway in C. elegans is associated with increased resistance to stress, including oxidative stress [ 18, 19, 20, 21].

  • Also of interest are genes that are upregulated in both the cancers, including IGFBP3 (insulin-like growth factor binding protein 3), which, interestingly, is thought to have proapoptotic activities [ 14 ] , and GSN (gelsolin), which has a role in cellular motility and acts as both a regulator and effector of apoptosis [ 15 ] . Further xenograft studies of the type presented here could examine the responses of the host tissue to the tumor (using a mouse microarray chip), as well as temporal changes in gene expression within the developing tumor.


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