Example sentences for: insulin-deficient

How can you use “insulin-deficient” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These data suggest that in fasting and insulin-deficient diabetes, as in leptin-deficient ob/ob mice [ 9 19 ] , glucocorticoids dominate leptin and insulin levels in determining AGRP expression, whereas insulin and leptin dominate glucocorticoids in determining hypothalamic POMC expression.

  • More importantly, the use of a sliding scale treatment might predispose to DKA in insulin-deficient patients before the development of hyperglycemic levels.

  • Glucocorticoids were also elevated, as expected, in insulin-deficient diabetes (Fig.

  • We had previously shown that fasting could regulate hypothalamic gene expression in insulin-deficient mice even though in these mice fasting did not influence plasma leptin or insulin [ 5 ] . Since adrenalectomy blocked the fasting-induced reduction in melanocortin tone in diabetic mice (as it had in euglycemic mice in the first study), these results suggest that effects of fasting on melanocortin tone in diabetic mice may be mediated at least in part by a rise in plasma corticosterone (itself possibly secondary to the reduction in plasma leptin).

  • On the other hand, blocking the rise in corticosterone by adrenalectomy prevented the reduction in hypothalamic POMC mRNA and the induction of AGRP mRNA, without reversing either the reduced leptin or the reduced adiposity, characteristic of insulin-deficient diabetic mice (Fig.


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