Example sentences for: inotropy

How can you use “inotropy” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To study this we directly measured developed pressures, myocardial oxygen consumption and used a newly developed technique to measure intracellular calcium in perfused mouse hearts with the calcium sensitive fluorescent dye rhod-2 [ 6 7 ] during calcium-induced inotropy and with dobutamine.

  • In the perfused mouse heart, high perfusate calcium positive inotropy compared to dobutamine results in reduced myofilament calcium responsiveness, decreased energetic efficiency and is dependent in part on protein kinase C activation.

  • The specific protein kinase C inhibitor chelerythrine significantly inhibited high calcium positive inotropy (2.

  • ; 4) to antagonize the effects of protein kinase C, the specific antagonist chelerythrine (ref 30; 10 nM, Calbiochem-Novabiochem Intl, La Jolla, CA) was added to the perfusate when inducing positive inotropy.

  • Thus, we predicted that high perfusate calcium positive inotropy would result in lower developed pressures relative to both intracellular calcium and myocardial oxygen consumption compared to dobutamine, and that high perfusate calcium would be associated with evidence of protein kinase C activation, though not dobutamine.


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