Words similar to inclusions

Example sentences for: inclusions

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The possibility that the inclusions induced by mycRab24(D123I) contain aggregated nuclear import complexes was further supported by immuno-staining with an antibody against importin-β (karyopherin-β), which revealed focal concentrations of importin-β in these structures (Fig.
Rab24 does not have a classic nuclear localization signal sequence, but monomeric mycRab24(D123I) is theoretically small enough (24 kDa) to diffuse across the nuclear pores [ 61 ] . However, it is less likely that this could occur in the case of the larger EGFP-Rab24(D123I) fusion construct (50 kDa), which also formed abundant intranuclear inclusions (Fig.
Interestingly, Rab24 has been implicated as a possible mediator of autophagy in a recent study where wild-type GFP-Rab24 was observed to accumulate on large autophagic vacuoles in cells subjected to amino acid starvation [ 43 ] . Thus, if Rab24(D123I) functions as a true dominant suppressor of endogenous Rab24, the inclusions observed in the present study may consist of misfolded endogenous proteins that cannot be degraded because basal activity of the autophagosome-lysosome pathway is blocked.
Disruption of nuclear architecture by inclusions containing Rab24(D123I)
To learn more about the structural features of Rab24(D123I) that are responsible for triggering the formation of nuclear inclusions, we focused on regions of the protein that distinguish Rab24 from other members of the Rab family.