Example sentences for: inclusions

How can you use “inclusions” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Here we have shown that single amino acid substitutions ( e.g. , D123I and T120A) in one of the conserved guanine nucleotide binding domains of Rab24 can cause the protein to accumulate in a massive array of nuclear inclusions in mammalian cells.

  • 10) suggest that the inclusions are complex protein assemblies containing Hsp70 and ubiquitin.

  • Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.

  • Introducing a formula to cover - ize /- ise variants (and some others) would have freed up space for more important inclusions.

  • The morphological changes occurring in cells with accumulated Rab24(D123I) inclusions did not match the hallmark features of apoptosis ( e.g. , membrane blebbing, condensation of chromatin at the nuclear periphery).


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