Words similar to inclusions

Example sentences for: inclusions

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Ultimately, the accumulation of nuclear inclusions in cells expressing Rab24(D123I) causes a catastrophic disruption of the nuclear architecture, although this does not appear to be accompanied by classic signs of apoptotic cell death such as DNA fragmentation or caspase activation.
The possibility that the inclusions induced by mycRab24(D123I) contain aggregated nuclear import complexes was further supported by immuno-staining with an antibody against importin-β (karyopherin-β), which revealed focal concentrations of importin-β in these structures (Fig.
Rab24 does not have a classic nuclear localization signal sequence, but monomeric mycRab24(D123I) is theoretically small enough (24 kDa) to diffuse across the nuclear pores [ 61 ] . However, it is less likely that this could occur in the case of the larger EGFP-Rab24(D123I) fusion construct (50 kDa), which also formed abundant intranuclear inclusions (Fig.
8A) and, contrary to expectations, did not interfere with the accumulation of the D123I mutant in nuclear inclusions (Fig.
Although Rab24 has been proposed as a possible regulator of autophagic processes [ 24 43 ] , the accumulation of punctate bodies in cells expressing Rab24(D123I) was not prevented by 3-methyadenine, a known inhibitor of autophagosome formation [ 44 ] . Most importantly, electron microscopy with immunogold labeling of mycRab24(D123I) in ultra-thin sections confirmed the initial impression that the inclusions are in fact localized within the nucleus.