Words similar to inclusions

Example sentences for: inclusions

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Mutant forms of Rab24 accumulate in nuclear inclusions
Ultimately, the accumulation of nuclear inclusions in cells expressing Rab24(D123I) causes a catastrophic disruption of the nuclear architecture, although this does not appear to be accompanied by classic signs of apoptotic cell death such as DNA fragmentation or caspase activation.
Here we have shown that single amino acid substitutions ( e.g. , D123I and T120A) in one of the conserved guanine nucleotide binding domains of Rab24 can cause the protein to accumulate in a massive array of nuclear inclusions in mammalian cells.
8A) and, contrary to expectations, did not interfere with the accumulation of the D123I mutant in nuclear inclusions (Fig.
The inclusions bear a superficial resemblance to those described in some of the polyglutamine disorders, and appear to sequester Hsp70, ubiquitin, importin-β, and glucocorticoid receptor.