Example sentences for: inclusions

How can you use “inclusions” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Therefore, a question raised by these studies is whether the genesis of nuclear inclusions occurs indirectly, through dominant suppression of endogenous Rab24 function by the D123I and T120A mutants, or directly, through association of cellular proteins with the accumulating mutant protein.

  • In all cases, these proteins exhibited a general cytoplasmic localization with no evidence of nuclear inclusions (Fig.

  • Nuclear inclusions generated by Rab24(D123I) contain ubiquitin and Hsp70

  • The molecular mechanism underlying the formation of nuclear inclusions in cells expressing the mutant forms of Rab24 remains to be defined.

  • Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.


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