Example sentences for: immortalized

How can you use “immortalized” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The advantage to using astrocyte lines is that many of these lines can maintain a monolayer in culture for long periods of time [ 6 ] . Since Tag levels are significantly determined by the strength of the transcription promoter in this retroviral system [ 1 11 ] , we examined cell lines immortalized by Tag transcribed from two different promoters.

  • Originally, we pursued a strategy of reduced Tag expression from the htk promoter as a means of producing immortalized, differentiated cells that may have a reduced transformation phenotype.

  • We asked whether Tag expression in immortalized mouse cells always increased as a function of G 1 time during exponential growth and whether levels eventually decreased or achieved a steady state level at high cell density.

  • Tag immortalized human tracheal epithelial (HTE) cells grown at different densities and assayed for cytokeratins 6 and 18 showed a density dependent decrease in cytokeratin immunoreactivity and a concomitant increase in %G 1 both in normal growth medium and in differentiation medium (Frisa & Jacobberger, unpublished).

  • Several heat shock proteins have been found in cell nuclei in the absence of stress [ 30 ] , and alpha-crystallin has been shown to interact directly with DNA [ 18 ] . AlphaB, expressed in transfected CHO cells, has been shown to ectopically localize to interphase nuclei, suggesting a regulatory role for this protein in the nucleus [ 19 ] . A subset of immortalized lens epithelial cells from alphaBKO mice have been shown to hyperproliferate [ 20 ] suggesting that alphaB may be important in maintaining genomic stability.

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