Example sentences for: imipenem

How can you use “imipenem” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Instead, we predict that the insertion of an aspartic acid into the active site at position 224 results in a change in the hydrogen bonding network in L1; this hydrogen bonding network is extensive in all metallo-β-lactamases that have been characterized crystallographically [ 37 42 44 45 48 49 62 63 ] . The N233D mutant also exhibited greatly reduced k cat values for biapenem and meropenem but not for imipenem or any of the other substrates tested.

  • On the other hand, experience with the drug in patients with cystic fibrosis, has shown only minimal nephrotoxicity [ 19 20 21 30 ] . Garnacho-Montero and coworkers [ 12 ] , in patients with VAP, observed that there was no significant difference in development of renal failure between colistin and imipenem.

  • Patients with VAP caused by A. baumannii were treated with imipenem (21 patients) or, in the case of resistance to all other antibiotics, with colistin (14 patients).

  • Three carbapenems were also used as substrates for L1, and biapenem, imipenem, and meropenem exhibited K m values of 32 ± 1 μM, 57 ± 7 μM, and 15 ± 4 μM and k cat values of 134 ± 4 s -1, 370 ± 5 s -1, and 157 ± 9 s -1, respectively (Table 5).

  • Achieving clinical cure in 57% of cases, intravenous colistin was as effective as imipenem.


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