Words similar to imbalance
Example sentences for: imbalance
How can you use “imbalance” in a sentence? Here are some example sentences to help you improve your vocabulary:
The significant increase in Qsp/Qt and decrease in PaO 2 in the patients affected by pruritus can be interpreted as the effect of an imbalance in the ventilation/perfusion ratio, induced by the vasodilating action of vancomycin on the pulmonary circulation, as supported by the significant reduction in pulmonary vascular resistance at time point 3. Also, the respiratory changes were significant only in patients of group A who were not treated with a β-blocker, whereas preopera-tive use of the drug eliminated any significant respiratory change.
For the patient, this is manifested as a degeneration of joint function, loss of mobility and concomitant increased morbidity and mortality [ 3 4 ] . For the clinician, this imbalance identifies a need for therapeutic agents to prevent cartilage loss [ 5 ] .
Our previous study showed that functional decline of mitochondria appears in the SOD1 G93Amice as early as 60 to 100 days of age [ 22 ] . This precedes the peak of mitochondrial vacuolation and the onset of the disease by two to three months [ 15 ] . Mitochondrial dysfunction can lead to energy deficiency and ionic imbalance [ 68 ] , elevated ROS and oxidative damage [ 69 ] , and increased sensitivity of neurons to excitotoxicity [ 19 70 71 72 ] . These effects could precipitate MVISE, which trigger cell death programs by releasing pro-apoptotic proteins resided in the mitochondrial intermembrane space, such as cytochrome c, AIF, SMAC/DIABLO, endo G and Htra/Omi [ 73 ] . The absence of cytochrome c in the porous large vacuoles and the presence of cytochrome c in the small vacuoles (Fig.
A computational technique termed comparative genomic microarray analysis (CGMA) has previously been used to identify regions of allelic imbalance indirectly from gene-expression profiles of human tumors [ 8].
While these CGMA-predicted regions were near the 35% cutoff for detection, they could represent other regions of allelic imbalance yet to be detected by CGH.
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