Example sentences for: imatinib

How can you use “imatinib” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • 0020075), the initial identification three years ago of resistance mutations against imatinib led to the rapid development of alternative kinase inhibitors that work even against tumors with the resistance mutation.

  • Gleevec (also known as STI571, Imatinib from Novartis Pharmaceutical Inc.), a recently FDA approved drug for chronic myelogenous leukemia, is an ATP analogue, and it competitively binds to and inhibits BCR-ABL tyrosine kinase, resulted from the chromosomal translocation t(9; 22).

  • This was first appreciated in patients with CML treated with imatinib whose tumors developed resistance, and has been most extensively studied in that context.

  • All kinases share some common features, and a resistance mutation very similar to the one identified here has also been found in other kinase genes from tumors with acquired resistance to imatinib, another kinase inhibitor.

  • Although imatinib inhibits different kinases in various diseases (BCR-ABL in CML, KIT or PDGFR-alpha in gastrointestinal stromal tumors [GISTs], and PDGFR-alpha in hypereosinophilic syndrome [HES]) (reviewed in [14]), some tumors that become refractory to treatment with imatinib appear to have analogous secondary mutations in the kinase-coding domain of the genes encoding these three enzymes.


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