Example sentences for: imatinib

How can you use “imatinib” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • For example, imatinib is effective in treatment of chronic myelomonocytic leukemia with gene rearrangements that constitutively activate PDGFRB [3], of hypereosinophilic syndrome with activating mutations in PDGFRA [4], and of gastrointestinal stromal cell tumors associated with activating mutations in KIT [5] (all reviewed in [6]).

  • 0020075), the initial identification three years ago of resistance mutations against imatinib led to the rapid development of alternative kinase inhibitors that work even against tumors with the resistance mutation.

  • Given the paradigm established with imatinib, other drug-resistance mutations in EGFR, either within or outside the tyrosine kinase domain, are likely to exist.

  • Such mutations, which cluster in four distinct regions of the ABL kinase domain (the ATP binding loop, T315, M351, and the activation loop), interfere with binding of imatinib to ABL [9,10,11].

  • As a consequence, there have been additional dividends from the United States Federal Drug Administration approval of imatinib for treatment of BCR-ABL-positive CML.


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