Example sentences for: imatinib

How can you use “imatinib” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Indeed, about three years after the recognition of imatinib resistance mutations in BCR-ABL-positive CML, new drugs are now in clinical trials that are potent inhibitors of imatinib-resistant BCR-ABL mutants [13,14].

  • For example, imatinib is effective in treatment of chronic myelomonocytic leukemia with gene rearrangements that constitutively activate PDGFRB [3], of hypereosinophilic syndrome with activating mutations in PDGFRA [4], and of gastrointestinal stromal cell tumors associated with activating mutations in KIT [5] (all reviewed in [6]).

  • This was first appreciated in patients with CML treated with imatinib whose tumors developed resistance, and has been most extensively studied in that context.

  • The new drugs bind to ABL in an “open” conformation, as opposed to imatinib, which binds ABL in a “closed” conformation [12,13].

  • Imatinib induces complete remission in most patients with CML in stable phase [1], and also has activity in CML that has progressed to blast crisis [2].


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