Example sentences for: imatinib

How can you use “imatinib” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Such mutations, which cluster in four distinct regions of the ABL kinase domain (the ATP binding loop, T315, M351, and the activation loop), interfere with binding of imatinib to ABL [9,10,11].

  • Given the paradigm established with imatinib, other drug-resistance mutations in EGFR, either within or outside the tyrosine kinase domain, are likely to exist.

  • This was first appreciated in patients with CML treated with imatinib whose tumors developed resistance, and has been most extensively studied in that context.

  • 0020075), the initial identification three years ago of resistance mutations against imatinib led to the rapid development of alternative kinase inhibitors that work even against tumors with the resistance mutation.

  • Our results further demonstrate that an analogous mechanism of acquired resistance exists for imatinib and EGFR tyrosine kinase inhibitors (Table 3), despite the fact that the various agents target different kinases in distinct diseases.


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