Example sentences for: imatinib

How can you use “imatinib” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • All kinases share some common features, and a resistance mutation very similar to the one identified here has also been found in other kinase genes from tumors with acquired resistance to imatinib, another kinase inhibitor.

  • The new drugs bind to ABL in an “open” conformation, as opposed to imatinib, which binds ABL in a “closed” conformation [12,13].

  • Indeed, about three years after the recognition of imatinib resistance mutations in BCR-ABL-positive CML, new drugs are now in clinical trials that are potent inhibitors of imatinib-resistant BCR-ABL mutants [13,14].

  • This was first appreciated in patients with CML treated with imatinib whose tumors developed resistance, and has been most extensively studied in that context.

  • Imatinib is also a potent inhibitor of the ARG, KIT, PDGFRA, and PDGFRB tyrosine kinases.


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