Words similar to ile
Example sentences for: ile
How can you use “ile” in a sentence? Here are some example sentences to help you improve your vocabulary:
The 18-mer duplex DNA encoding the insertion peptide (Ile-Asn-Asn-Glu-Thr-Ile) was ligated with Hpa1 digested pKK-RT66 in between codon 135 and 136.
The airy, bright Baroque church of St-Louis-en-l’Ile illuminates with a golden light its fine collection of Dutch, Flemish, and Italian 16th- and 17th-century art.
The two flaps fold over the inhibitor to form a tunnel-shaped active site and are held in this close position by hydrogen bonding from Ile50 and Ile50' NH groups of the enzyme to a water molecule, which in turn is hydrogen bonded to the P2 and P1' CO groups of the inhibitor [ 24 ] . The bonding stabilizes the flaps in a closed position and inhibits the activities of the enzyme.
All crystallographically characterized metallo-β-lactamases have a flexible amino acid chain that extends over the active site [ 37 42 44 45 46 47 48 49 ] . Previous NMR studies on CcrA have shown that this loop "clamps down" on substrate or inhibitor upon binding, and there is speculation that the distortion of substrate upon clamping down of the loop may drive catalysis [ 50 ] . The crystal structure of L1 showed that there is a large loop that extends over the active site, and modeling studies have predicted that two residues, Ile164 and Phe158, make significant contacts with large, hydrophobic substituents at the 2' or 6' positions on penicillins, cephalosporins, or carbapenems [ 37 ] . To test this prediction, Ile 164 and Phe158 were changed from large, hydrophobic residues to alanines to afford the I164A and F158A mutants.
Behind the hotel, beyond an 1898 statue of Samuel de Champlain, the city’s founder, Dufferin Terrace offers a magnificent view over the St. Lawrence and downriver to the Ile d’Orléans.
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