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Example sentences for: iiib

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Since elicitation of gp41 six-helix bundles might be involved in, or contribute to the virucidal activity of candidate microbicides, it was of interest to determine whether anionic polymers other than CAP also induced six-helix bundle formation in HIV-1 IIIB and BaL virus particles.
The validation sample included 153 chemotherapy-naive patients with stage I, II, IIIa, or IIIb breast cancer who had been treated with adjuvant chemotherapy during 1986-92 as part of the MD Anderson Cancer Center (MDACC) 86-12 trial.
Ten million MT-4 cells were incubated with either 1 ml virus stock (2 multiplicity of infection (MOI) units of strain IIIB) or 1 ml mock virus for 3 h at 37°C.
Surprisingly, and unlike with mAb 2F5 [ 8 ] specific for the C-terminal region of the gp41 ectodomain [ 33 ] , CAP treatment enhanced the binding of both HIV-1 IIIB and HIV-1 BaL to mAb NC-1, reacting with gp41 six-helix bundles from both HIV-1 IIIB and BaL (Fig.
As a result of interaction with micronized CAP (in the form of Aquateric), the integrity of both HIV-1 IIIB and HIV-1 BaL virus particles was strikingly affected as indicated by the observation that most of the p24 antigen after virus contact with micronized CAP was no longer precipitable by 3% polyethylene glycol 6000 (PEG) unlike p24 antigen within untreated virus particles which precipitates under these conditions (Fig.