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Example sentences for: iiib

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CAP binding to HIV-1 IIIB particles most profoundly affected their binding to the V3 loop specific mAbs 9284 [ 26 ] and 9305 [ 27 ] and to the coreceptor CXCR4, while binding to sCD4; to virus neutralizing mAbs specific for the CD4 binding site on gp120, b12 [ 28 ] and 588D [ 29 ] ; to mAb 17b specific for a discontinuous conserved epitope proximal to the binding site for both CD4 and anti-CD4 binding site antibodies [ 30 ] ; to mAb 2G12 specific for an epitope centered around the C3/V4 domain of gp120 also involving N-linked glycans [ 31 ] and to the gp41 specific mAb 2F5 [ 32 ] was less affected.
1) and HIV-1 IIIB and BaL virus particles (Fig.
Among the two carboxylate polymers (Carbomer 974P and CAP), only soluble CAP (at neutral pH) was able to elicit the formation of gp41 six-helix bundles in both HIV-1 IIIB and BaL and was virucidal against both of these viruses.
Similarly, pretreatment of HIV-1 with sCD4 resulted in subsequent increased binding of virus with CAP, the effect being much more pronounced with HIV-1 BaL in comparison with HIV-1 IIIB (Fig.
Since elicitation of gp41 six-helix bundles might be involved in, or contribute to the virucidal activity of candidate microbicides, it was of interest to determine whether anionic polymers other than CAP also induced six-helix bundle formation in HIV-1 IIIB and BaL virus particles.