Words similar to ige-dependent

Example sentences for: ige-dependent

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In humans, antigen-specific anaphylactic reactivity is thought to be mediated solely (or primarily) by IgE antibodies, whereas it has long been known that either IgE or IgG1 antibodies can mediate anaphylaxis in mice (reviewed in [ 14 15 ] and [ 17 ] ). However, it has been reported that IgG1-dependent anaphylaxis in the mouse is associated with substantially less histological evidence of mast cell degranulation than is observed in IgE-dependent anaphylaxis in that species [ 17 ] . In neither of the models of "autoimmunity" that we have studied (i.e.
recently demonstrated that strong IgG1 responses can be induced in NOD mice that have been immunized subcutaneously with insulin B chain peptides administered in physiological saline [ 15 ] . However, both studies showed that anaphylaxis can be induced in such mice upon subsequent re-challenge with preparations of the peptides used for immunization [ 15 ] . Moreover, the anaphylactic reactions in mice that had been immunized and challenged with G7 peptides were severe, with reductions in body temperature that were very similar to those observed in mice exhibiting IgE-dependent passive systemic anaphylaxis and with a very high fatality rate (12/14 mice, or 86%).