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Example sentences for: ifkb

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As only the 3' flanking sequence of the blasticidin resistance cassette is found in ifkB but not the 5' flanking sequence, the disruption construct should be specific for
Searches of the Dictyostelium sequence databases revealed two potential GCN2-like genes that we named ifkA and ifkB (initiation factor kinase).
The predicted amino acid sequences of IfkA and IfkB are nearly identical within the kinase domain and the HisRS domain, and in turn these two domains share significant sequence identity with GCN2 proteins from yeast, Drosophila , and mammals.
The insert in IfkA and IfkB is significantly longer than that of other GCN2 proteins.
GCN2 of yeast and mammals is a known sensor of amino acid starvation and regulates cellular responses to such starvation [ 24 25 ] . Using degenerate primers and PCR and database searching identified two GCN2-like genes in Dictyostelium , ifkA and ifkB . Thinking that one or both of these genes may play a role in sensing amino acid starvation and in initiating development, we carried out the work described herein to examine their functions.