Example sentences for: ia

How can you use “ia” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The latter was evaluated indirectly using a recombinant chimeric protein containing the extracellular domain of the BMP receptor type IA fused to the immunoglobulin Fc domain (BMPR-IA-Fc).

  • There is substantial debate regarding the cost-benefit ratio of population screening [ 4 5 6 7 8 ] . Restricting screening to those individuals at high risk both for developing IA and for rupture would improve the cost-benefit ratio.

  • For instance, coexpression of type II BMPR with either IA or IB BMPR increases ligand-binding affinity and dramatically enhances biologic activity [ 11].

  • About 90% of SAH cases are caused by a ruptured IA [ 1 ] . Per-case mortality for ruptured IAs is about 30 to 50% and morbidity about 66% as opposed to about 2% mortality and 4% morbidity for elective surgery of unruptured IAs in asymptomatic low-risk patients [ 2 3 ] . Given the marked contrast between the outcomes of elective versus emergency surgery, the goal has to be identification and treatment of IAs prior to rupture.

  • BMPs activate Smad-1 by binding to type I and type II serine-threonine kinase receptors [ 40 41 ] . Specific receptor subunits shown to bind BMPs include BMP receptor type IA (BMPR-IA), BMPR-IB, BMR-II, activin receptor type I (ActR-I), and ActR-II [ 42 43 44 ] . BMP ligands can bind to either type I or type II receptor subunits independently, but both receptor types are required for high-affinity binding and signaling [ 40 ] . The finding that the soluble BMPR-IA-Fc chimera significantly inhibits BMP-5 induced dendritic growth suggests that BMP-5 may be activating the Smad-1 signaling pathway via interactions with BMPR-IA.

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