Words similar to hypersensitive
Example sentences for: hypersensitive
How can you use “hypersensitive” in a sentence? Here are some example sentences to help you improve your vocabulary:
The inability of type 2 viruses to confer a higher mutation rate than type 1 viruses in the non-HSV DNA mutagenesis assay is consistent with the absence of S1 nuclease hypersensitive sites in the LacZ gene fragment.
Loss of this enzymatic activity renders yeast cells temperature-sensitive for growth on galactose medium and hypersensitive to mild mutations in the yeast homolog of mammalian Cdk7, that is, Kin28, the kinase component of general transcription factor TFIIH [ 30].
Recently, discovery that the Hint-homologous HNT1 gene is required for high temperature growth on galactose and observations that alleles of cak1 , kin28 , ccl1 and tfb3 are hypersensitive to loss of Hnt1 enzyme activity provided evidence that Hnt1 enzyme activity positively regulates Kin28 function, particularly on galactose media [ 9 ] . Though phenotypic consequences of hnt2 mutations have yet to be discovered, our observations suggest that synthetic lethal interactions with hnt2 mutations are likely to be found in adenine prototrophic strains undergoing heat shock.
GshA-deficient strains of A. thaliana are viable, but are hypersensitive to cadmium [ 39].
In response to DNA damage induced by ionizing radiation or chemical agents such as cisplatin, ATM kinase is activated and phosphorylates a number of downstream regulatory proteins important for cell cycle arrest, growth control, apoptosis and DNA repair [ 25 26 27 28 ] . AT patients are known to be predisposed to a variety of cancers, and the fibroblasts of AT patients are hypersensitive to ionizing radiation [ 29 ] . Although many reports showed the association of ATM mutation with risk of a number of different human malignancies, including prostate cancer, breast cancer, ovarian cancer, B-cell chronic lymphocytic leukemia and mantle cell lymphoma, the underlying molecular mechanism by which ATM gene causes these changes are not well understood [ 30 31 32 33 34 35 ] . There is so far no study showing the association of ATM gene with any solid tumor.
Loading...