Words similar to hypermethylation

Example sentences for: hypermethylation

How can you use “hypermethylation” in a sentence? Here are some example sentences to help you improve your vocabulary:

Promoter hypermethylation was not found in normal testes for any of the tested genes except CDH1 . CDH1 exhibited methylation in two of the four normal testes analyzed.
We also showed that the hypermethylation leads to loss of expression in most of the genes and reactivate upon treatment with demethylating drug 5-Aza-2' deoxycytidine.
The rare CpG hypermethylation seen in five SGCT patients may be due to the existence of a minor NSGCT component that might have escaped the histologic diagnosis.
A unique feature of GCTs is their origin from germ cells at a stage in development where they undergo epigenetic reprogramming [ 6 13 ] . The absence of this epigenetic modification in SGCTs is consistent with their GC-like nature as previously noted [ 6 14 ] . On the other hand, the extensive promoter hypermethylation seen in NSGCTs suggests a mechanistic role in their potential for embryonal and extra-embryonal lineage differentiation [ 6 14 ] . Establishment of DNA methylation in the mammalian genome is controlled by at least three DNA methyltransferases (DNMTs), DNMT1 , DNMT3a and DNMT3b [ 15 ] . The role of these DNMTs in differential de novo methylation in SGCT vs.
To investigate such a role, we evaluated the status of promoter hypermethylation of 21 genes in GCT specimens and cell lines.