Words similar to hypermethylated
Example sentences for: hypermethylated
How can you use “hypermethylated” in a sentence? Here are some example sentences to help you improve your vocabulary:
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
This gene has been shown to be hypermethylated in tumors arising from breast-ovarian cancer syndrome [ 32 ] . Although we detected complete promoter methylation of BRCA1 gene in only 6% of primary tumors, other mechanisms that inactivate this gene might exist.
Since a number of gene promoters were hypermethylated and showed down-regulated mRNA in GCT, we wanted to test whether hypomethylation reactivates the gene expression in these tumors.
The overall higher frequency of promoter methylation seen in NSGCTs is noticeably evident in DNA repair genes RASSF1A, BRCA1 , and MGMT , and the hypermethylated in cancer 1 ( HIC1 ) gene, which encodes a transcription factor.
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