Words similar to huape

Example sentences for: huape

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Mutations that greatly diminish the enzymatic activity of huAPE1 do not affect, and may even increase binding to damaged DNA, while non-specific DNA binding remains low [ 16 18 ] . Further, mutations that have little effect on APE activity in vitro prevent complementation of DNA repair deficient E. coli . As seen with other DNA repair enzymes [ 19 ] , specificity determining residues, as yet unidentified for APEs, must be distinct from those involved in phosphorolysis.
A PSIBLAST search, using huAPE1 as the founder sequence, with an e-value of 0.1 per iteration, did not converge after 6 iterations, but few new sequences were added in the last 2 cycles.
The 12 conserved molegos form the β-barrel core of huAPE1.
The completely conserved residues of huAPE1 concentrate, for the most part, at one end of this framework to form the metal ion binding active site (Figure 4).
The importance of such bonds for activity was shown in other work, where huAPE1's binding to the DNA backbone is only inhibited by ethylation of the phosphates two and three positions 3' to an abasic site [ 18 ] . Mutation of R177A, at the end of Molego 6, that binds to this region and to the bases opposite the AP-site had enhanced activity [ 11 ] , while mutations at W280 (Molego 11) and F266 (Molego 10) [ 33 ] reduce activity and, in the latter case, substrate selectivity.