Words similar to huape

Example sentences for: huape

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We then demonstrated that the shared molegos served a similar role in substrate binding by comparing the DNA binding profile of huAPE1 with that for the less specific enzyme DNase 1. The molegos present in both enzymes interact with target DNA in a similar fashion, while residues in molegos distinctive for APE1 control specificity by binding primarily to the bases around the apurinic site.
Both enzymes cleave only one DNA strand in a duplex and bacterial Xth cleaves ssDNA containing an abasic site [ 42 ] . The additional contacts huAPE1, compared to DNase 1 (Figure 6), makes 3' to the damage site and to the opposite strand lower its turnover rate and its potential to cleave normal DNA.
The 12 conserved molegos form the β-barrel core of huAPE1.
The completely conserved residues of huAPE1 concentrate, for the most part, at one end of this framework to form the metal ion binding active site (Figure 4).
, rapidly releasing substrate/product), relatively non-specific DNase1 as opposed to the processive, highly specific huAPE1.