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Example sentences for: huape

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The importance of such bonds for activity was shown in other work, where huAPE1's binding to the DNA backbone is only inhibited by ethylation of the phosphates two and three positions 3' to an abasic site [ 18 ] . Mutation of R177A, at the end of Molego 6, that binds to this region and to the bases opposite the AP-site had enhanced activity [ 11 ] , while mutations at W280 (Molego 11) and F266 (Molego 10) [ 33 ] reduce activity and, in the latter case, substrate selectivity.
The 12 motifs are also structurally conserved, as demonstrated by the low RMSD values between segments in the crystal structures of bacterial ExoIII and of huAPE1.
A PSIBLAST search, using huAPE1 as the founder sequence, with an e-value of 0.1 per iteration, did not converge after 6 iterations, but few new sequences were added in the last 2 cycles.
A contact plot of huAPE1 with the DNA in the 1DE8 crystal structure (Figure 5) shows that motifs 1-3,5-8, and 10-12 all have residues close to the substrate, an oligonucleotide containing an abasic site (AP-DNA).
Both enzymes cleave only one DNA strand in a duplex and bacterial Xth cleaves ssDNA containing an abasic site [ 42 ] . The additional contacts huAPE1, compared to DNase 1 (Figure 6), makes 3' to the damage site and to the opposite strand lower its turnover rate and its potential to cleave normal DNA.