Words similar to huape

Example sentences for: huape

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Mutations that greatly diminish the enzymatic activity of huAPE1 do not affect, and may even increase binding to damaged DNA, while non-specific DNA binding remains low [ 16 18 ] . Further, mutations that have little effect on APE activity in vitro prevent complementation of DNA repair deficient E. coli . As seen with other DNA repair enzymes [ 19 ] , specificity determining residues, as yet unidentified for APEs, must be distinct from those involved in phosphorolysis.
The 12 conserved molegos form the β-barrel core of huAPE1.
The completely conserved residues of huAPE1 concentrate, for the most part, at one end of this framework to form the metal ion binding active site (Figure 4).
Both enzymes cleave only one DNA strand in a duplex and bacterial Xth cleaves ssDNA containing an abasic site [ 42 ] . The additional contacts huAPE1, compared to DNase 1 (Figure 6), makes 3' to the damage site and to the opposite strand lower its turnover rate and its potential to cleave normal DNA.
The 12 motifs are also structurally conserved, as demonstrated by the low RMSD values between segments in the crystal structures of bacterial ExoIII and of huAPE1.