Words similar to hpb-all
Example sentences for: hpb-all
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Cdc42 has been implicated in the formation of small, actin-rich filopodia [ 34 ] , which are similar to those seen on spread HPB-ALL cells (figure 5) around the periphery of the cell body and extended pseudopods.
C3 (25 μg/ml) was electroporated into the T cell line HPB-ALL as described in the Materials and Methods.
Although Rac1 and Cdc42 were identified in western blots of whole cell lysates prepared from the T cell lines HPB-ALL, CEM, HSB (data not shown), and PB human T lymphocytes (data not shown), there was no detection of ribosylation in the lower molecular weight Rac and Cdc42 related GTPases in HPB-ALL cells, indicating the specificity of C3.
This phenotype also coincided with the complete loss of cellular motility in HPB-ALL, even though adhesion to substrate was not noticeably altered.
However, we have recently demonstrated that induced adhesion of primary T lymphocytes to fibronectin is unaffected by Rho inactivation [ 25 ] , and data presented here suggests that constitutively high adhesion of HPB-ALL cells to β1 integrin substrate is unaffected by C3 treatment.
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