Words similar to homomeric
Example sentences for: homomeric
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It has been shown that NR1 possesses all the properties characteristic of the NMDA receptor channel complex [ 4, 7, 9, 10, 11, 12] whereas the NR2 subunit has no independent channel activity in its homomeric structure but potentiates the NMDA receptor activity when expressed in combination with the NR1 subunit [ 4, 13, 14].
Based on data obtained from affinity labeling and site directed mutagenesis studies, several regions of the nicotinic acetylcholine receptor have been implicated in ligand binding [ 10 ] . Six essential loops appear to contribute to the binding site with the position of each loop differing slightly depending on whether the receptor is heteromeric or homomeric [ 4 ] . For homomeric receptors such as the α7 nAChR, the loops are identified as A, B, C, D, E and F [ 4 11 ] . The amino acids that interact with ligands presumably extend into the binding site from these loops.
Two splice variants of an A subunit (long and short forms), and a single B subunit have been cloned [ 10 11 12 13 ] . Both the long and short forms of the A subunit are capable of forming functional homomeric receptors [5-HT 3AL R and 5-HT 3AS R] although some differences between an agonist and partial agonist activity have been observed [ 14 ] . A third subtype is formed by a combination of the A and B subunits to produce a heteromeric receptor of unknown stoichiometry [ 10 ] . Heteromeric receptors are pharmacologically and functionally distinct from the homomeric 5-HT 3AL and 5-HT 3AS receptors [ 11 ] .
The 200 kDa band represents the homomeric VR1 dimer whereas the 180 kDa band represent the homomeric Δ2-52 dimer.
If the higher molecular weight band does represent a dimer of subunits, the heteromeric VR1/Δ2-52 ought to be intermediate in size between the homomeric dimers.
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