Words similar to homologue
Example sentences for: homologue
How can you use “homologue” in a sentence? Here are some example sentences to help you improve your vocabulary:
3 region to which RASSF1A maps undergoes deletions in many solid tumor types, including GCTs [ 9 ] . RASSF1A encodes a splice variant of human RAS effector homologue, which interacts with the XPA protein and functions as a negative regulator of cell growth [ 16 17 ] . RASSF1A has been shown to be inactivated by promoter methylation in a variety of tumor types [ 16 17 18 19 ] . The 17q21 and 17p13 regions, to which BRCA1 and HIC1 map, respectively, also have been characterized by high frequency of LOH in GCT [ 9 ] . The BRCA 1 gene plays critical roles in DNA repair and recombination, cell cycle checkpoint control, and transcription and has been shown to be hypermethylated in breast-ovarian cancer [ 4 ] . The HIC1 gene is also often hypermethylated in many human cancers [ 20 21 22 ] . The DNA repair gene MGMT encodes O(6)-methylguanine-DNA methyltransferase and this enzyme effectively removes DNA adducts formed by alkylating agents [ 23 ] . Epigenetic inactivation of the MGMT gene was reported in a wide variety of cancers [ 24 25 ] . Also, a low frequency of methylation of the APC , RARB , and FHIT genes was detected in NSGCTs.
An NCBI BLAST search identified the murine homologue of yeast ELO2 (Elovl2) to be Ssc2 (Sequence similarity to Cig30), predominating in liver and testes [ 62 ] ; complementation studies in yeast mutants indicated the functional equivalent of ELO3 (Elovl3) is Ssc1 [ 35 ] . Substrates of mouse Ssc2 were AA and EPA (DHA was not tested) [ 35 ] . Thus, FUNG and FISH feeding may transcriptionally regulate their subsequent conversion to elongated products.
Drosophila Boule mutants was defective in the translation of the meiosis-specific CDC25 homologue, Twine [ 11 ] , and DAZL was found to be associated with polyribosomes in mouse testes [ 12 ] . More recently, DAZL was shown both in vitro and in a yeast three-hybrid system to bind specifically to oligo(U) stretches interspersed by G or C residues, including a U-rich segment in the 5' UTR of mouse Cdc25C mRNA [ 13 ] .
The neurotoxin P2 (35 ammo acids), another short toxin and a structural homologue of short insectotoxin II and 15, shows toxicity towards Sarcophaga falculata and crustaceans [ 26 ] . Chlorotoxin, isolated from Leiurus quinquestriatus haebraeus, shows Cl -channel-blocking activity and causes paralysis due to the inhibition of structurally related anion channels such as the extrajunctional channels of arthropod muscles [ 11 ] . It has also been reported that the short insectotoxin I5A may act on a "glutamate receptor of the postsynaptic membrane" [ 22 ] . Although no specific experimental evidence is available on the mode of action of ButaIT, it is assumed that ButaIT exerts similar ion channel blocking activity as that of other short insect toxins.
homologue of adenylyl cyclase-associated proteins), Enabled (Ena) and Abelson (Abl).
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