Words similar to holoenzyme
Example sentences for: holoenzyme
How can you use “holoenzyme” in a sentence? Here are some example sentences to help you improve your vocabulary:
The recruitment model for transcriptional activation stipulates that eukaryotic transcription is driven mainly by recruitment of preformed RNA polymerase holoenzyme to specific sites on the DNA [ 3 ] . According to this model, peptides may bind one of numerous proteins that guide holoenzyme to the lexA binding site.
Given the diversity of proteins that comprise holoenzyme, this model implies that many sequences of different types would be competent activators; their sole requirement would be to bind proteins within holoenzyme [ 3 ] . The acidic peptides may interact in a manner akin to native activators [ 7 ] . But the basic ones may, for example, bind other proteins that contain acidic regions, thereby forming a bridge to holoenzyme.
The 1.0 MDa complex contains yCCR4, yPOP2 (also referred to as yCAF1) and at least five yNOT1-5 proteins [ 5 6 7 ] . In this complex, yPOP2 independently binds to yCCR4 and yNOT1, and is absolutely required for yCCR4 to associate with the 1.0 MDa complex [ 6 7 ] . In the 1.9 MDa complex, yCCR4 binds to proteins such as yDBF2, a cell-cycle regulated protein kinase [ 2 ] , yCAF4 and yCAF16, and is essential for the interaction of both yCAF4 and yCAF16 with ySRB9, a component of the RNA polII holoenzyme [ 8 ] . yCCR4 was also reported to be associated with Paf1, Cdc73, and Hpr1 in a RNA polII complex distinct from the SRBP-containing holoenzyme [ 9 ] . Accordingly, yCCR4 contains, in its central region, a leucine-rich repeat (LRR) domain [ 10 ] which was demonstrated to be necessary for yCCR4 binding to the yPOP2 [ 5 11 ] , yDBF2 [ 2 ] , yCAF4 and yCAF16 [ 8 ] components of the CCR4-NOT complex.
Such proteins include components of holoenzyme and perhaps other factors [see ref.
In addition, BRCA1 can act as a transcriptional transactivator in yeast reporter assays [ 26, 27] and binds the RNA polymerase II holoenzyme, a component of the basal transcription machinery [ 25].
Loading...