Words similar to holoenzyme
Example sentences for: holoenzyme
How can you use “holoenzyme” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, the functional viral RdRP, as detailed later for RSV, is a complex holoenzyme composed of viral as well as cellular proteins [ 17 18 19 20 21 22 23 ] . Second, many NNR viral genomes and proteins are currently expressed from vaccinia-based cDNA clones, which generally requires superinfection by vaccinia virus [ 22 23 ] . Unfortunately, vaccinia virus itself is a major modulator of cellular signaling, including MAP kinase pathways and the actin cytoskeleton [ 24 25 26 ] . It is, therefore, virtually impossible to study the interaction between cellular signaling pathways and NNR viruses in cells that are also superinfected by vaccinia virus [ 24 25 26 ] . Third, mutations in the recombinant DNA are "permanent", and thus, the mutational phenotype cannot be switched on at pre-determined time points in infection.
In addition, BRCA1 can act as a transcriptional transactivator in yeast reporter assays [ 26, 27] and binds the RNA polymerase II holoenzyme, a component of the basal transcription machinery [ 25].
The recruitment model for transcriptional activation stipulates that eukaryotic transcription is driven mainly by recruitment of preformed RNA polymerase holoenzyme to specific sites on the DNA [ 3 ] . According to this model, peptides may bind one of numerous proteins that guide holoenzyme to the lexA binding site.
Given that this domain lies in the periphery of the holoenzyme, it is likely to participate in interactions with cofactors, which is compatible with the protein-protein interaction function identified in several proteins with the β-grasp fold [ 80 81 ] .
Given the diversity of proteins that comprise holoenzyme, this model implies that many sequences of different types would be competent activators; their sole requirement would be to bind proteins within holoenzyme [ 3 ] . The acidic peptides may interact in a manner akin to native activators [ 7 ] . But the basic ones may, for example, bind other proteins that contain acidic regions, thereby forming a bridge to holoenzyme.
Loading...