Words similar to holoapp
Example sentences for: holoapp
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Conversely, DN ROCK1 alone activated shedding of sAPP α . Cellular levels of holoAPP were not affected by transfection (Figure 5; p < 0.05 versus GFP control).
Typical maturation and half-life of mature cellular holoAPP were observed, as was subsequent release of sAPP α [5,29].
The pathway leading to AICD must be initiated by ectodomain shedding: holoAPP cannot directly give rise to AICD.
Instead, the pattern that we observed raises the possibility that statins, presumably via isoprenoids (given the reversibility with mevalonate), as discussed in the next section, may alter sorting of cellular holoAPP, diverting holoproteins away from terminal degradation in the endosomal/lysosomal pathway and into the constitutive secretory pathway that generates sAPP α . However, the fold effect on reduced intracellular turnover in the endosomal/lysosomal pathway (or sorting out of the endosomal/lysosomal pathway and into the constitutive secretory/shedding pathway) is apparently insufficient to explain the fold effect on sAPP α generation (2-fold for the former, vs 3- to 4-fold for the latter), indicating a contribution from a downstream site in the processing pathway.
For the detection of holoAPP and sAPP α , samples were separated in 7.5% polyacrylamide gels, transferred to nitrocellulose, and the proteins detected with either 369 (1:3,000 for holoAPP and C-terminal fragments) or 6E10 (1:1,000 for holoAPP or sAPP α ), followed by incubation of the transfers with appropriate secondary anti-rabbit or anti-mouse antibodies.
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