Words similar to holoapp
Example sentences for: holoapp
How can you use “holoapp” in a sentence? Here are some example sentences to help you improve your vocabulary:
As shown in Figure 6, arachidonic acid reduced the shedding of sAPP α without altering levels of holoAPP.
In the same experiment, levels of holoAPP were modestly increased but, again, to an extent insufficient to account for the increase in shed sAPP α (Figure 3).
Instead, the pattern that we observed raises the possibility that statins, presumably via isoprenoids (given the reversibility with mevalonate), as discussed in the next section, may alter sorting of cellular holoAPP, diverting holoproteins away from terminal degradation in the endosomal/lysosomal pathway and into the constitutive secretory pathway that generates sAPP α . However, the fold effect on reduced intracellular turnover in the endosomal/lysosomal pathway (or sorting out of the endosomal/lysosomal pathway and into the constitutive secretory/shedding pathway) is apparently insufficient to explain the fold effect on sAPP α generation (2-fold for the former, vs 3- to 4-fold for the latter), indicating a contribution from a downstream site in the processing pathway.
Conversely, DN ROCK1 alone activated shedding of sAPP α . Cellular levels of holoAPP were not affected by transfection (Figure 5; p < 0.05 versus GFP control).
Secretory maturation toxicity is one possible mechanism for elevated levels of intracellular mature holoAPP and causes retarded conversion of mature holoAPP to sAPP α . This pattern was not observed following statin treatment, excluding maturation toxicity as a mechanism underlying the altered levels of mature cellular holoAPP.
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