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Example sentences for: hnot
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Several components of the yCCR4-associated complexes have already been identified in humans: two homologs of yPOP2 (named hCAF1 and hPOP2/hCALIF) [ 16 17 18 19 ] , and homologs of NOT proteins (named hNOT1, hNOT2, hNOT3, hNOT4) [ 19 ] . Moreover, interactions between these proteins were demonstrated [ 19 20 ] . Yet, at the present time there has been no report of a human protein that would be structurally and functionally close to yCCR4.
However, at variance with hPOP2, hCAF1 is not able to interact with hNOT1 (nor with hNOT3) [ 19 ] . This suggests that human cells may contain at least two complexes involving a CCR4/POP2 association, a CCR4-NOT-POP2 complex analogous to the CCR4-NOT yeast complex, and a still unknown CCR4-CAF1 containing complex.
Indeed, both human homologs of yPOP2, hCAF1 and hPOP2, lack the 148 N-terminal amino acids which are, in yPOP2, required for transcriptional activation, whereas the yPOP2 C-terminus, which is involved in the interaction with yCCR4, is conserved in hCAF1 [ 11 ] and hPOP2 [ 19 ] . Similarly, hNOT2, the human homolog of the yNOT2 component of the CCR4-NOT complex, harbors a N-terminal domain divergent from that of yNOT2 -required for transcriptional activation and interaction with the yeast ADA2 factor-, but has conserved the C-terminal domain which is absolutely required for the yCCR4-associated function of yNOT2 [ 19 20 ] . Therefore, it looks as if genes of the CCR4-NOT complex have undergone a "concerted" phylogenetic evolution, with the yeast genes encoding multifunctional proteins and the animal genes only encoding "specialized" proteins specific for the CCR4-NOT complex.
A previous report [ 19 ] identified the human orthologs of yPOP2 (hPOP2/CALIF) and yNOT1 (hNOT1), and showed that they have conserved their ability to bind to each other.
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