Words similar to hne
Example sentences for: hne
How can you use “hne” in a sentence? Here are some example sentences to help you improve your vocabulary:
This study was designed to examine morphological alterations in RPE during oxidative stress, the involvement of ERK MAP kinase and 4-HNE and to test the hypothesis that PPARγ activation can prevent oxidative damage on RPE cells.
Several laboratories have attempted to document the formation of 4-HNE protein adducts during oxidative stress by Western blot analysis.
An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .
This study demonstrates that oxidative stress induced by H 2 O 2 could lead to RPE cell death, which is preceded by distinct morphological changes, ERK activation and 4-HNE protein adduct formation.
However, no specific protein was positively identified [ 63 ] . More recently, the formation of 4-HNE protein adducts was also demonstrated by Western blot analysis from the heart [ 64 ] , the liver [ 65 ] and the kidney [ 66 ] under oxidative stress.
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