Words similar to hla-autoimmune

Example sentences for: hla-autoimmune

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Moreover, direct estimates of the allele-specific effects of heterozygosity (relative to the corresponding homozygotes), nearly absent in the infectious disease-HLA literature, are frequently found in studies of HLA genotype and chronic (mostly autoimmune) diseases [ 28 29 30 ] . We do not know the reason for this difference in approach, but suspect that some infectious disease investigators, informed by the evolutionary hypothesis of overdominance for infectious disease resistance and by animal studies, may have a special interest in detecting effects of heterozygosity per se . Many studies of HLA-autoimmune disease associations, on the other hand, seem to focus more on the effects of individual alleles and, having established these, move on to investigate the dependence of these effects on genetic modifiers, including the identity of the individual's other allele at the same locus.