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Example sentences for: hhh

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5) predicted the presence of a potential Helix-hairpin-Helix (HhH) fold in members of the RAD52 superfamily.
Detection of bacterial homologs of RAD52 and identification of an aberrant HhH domain in these proteins
The third superfamily, typified by the yeast RAD52 protein and previously detected only in eukaryotes, was shown to include bacterial and phage homologs and to contain a modified HhH domain.
Although these predicted HhH modules are very divergent in sequence from the typical versions, the hairpin in both HhH modules of the RAD52 family proteins is bounded by small residues, typically glycine; this conforms to the signature motif characteristic of the classical HhH modules [ 28 29 ] . However, in the case of the RAD52 superfamily the predicted HhH modules appear to have been welded into a large globular superstructure that maintained its evolutionary distinctness over time.
The HhH domain is a small nucleic acid-binding module comprised of two helices joined by a central loop (hairpin), which functions as the DNA-binding moiety of numerous repair and recombination proteins [ 27 28 ] . Two HhH modules are predicted in the core conserved domain of the RAD52 family, the first one bounded by the predicted helices 2 and 3, and the second one bounded by helices 5 and 6 (Fig.