Words similar to hh-signaling
Example sentences for: hh-signaling
How can you use “hh-signaling” in a sentence? Here are some example sentences to help you improve your vocabulary:
The Hh-signaling pathway comprises three main components: the Hh ligand; a transmembrane receptor circuit composed of the negative regulator Patched (Ptc) plus an activator, Smoothened (Smo); and finally a cytoplasmic complex that regulates the Cubitus interruptus (Ci) or Gli family of transcriptional effectors.
These data show that the Hh-signaling inhibitors, but not structurally related inactive compounds, can significantly compete with the binding of the Hh agonist to Smo membranes.
Small-molecule modulators of growth-factor pathways have proven valuable in providing enhanced understanding of the intracellular events that occur subsequent to receptor activation, and in establishing the biological functions of these pathways [ 6 7 8 ] . In Hh signaling, multiple insights have been gained through the use of the plant-derived Hh antagonist cyclopamine [ 9 10 11 12 13 14 15 16 ] and a recently identified synthetic small-molecule Hh-signaling inhibitor, Cur61414 [ 17 ] . Interestingly, these specific inhibitors of Hh signaling appear to function downstream of Ptc but their precise molecular target(s) and mechanism of action are unknown.
Various studies in mammals have shown that Hh genes are expressed in discrete areas of the adult organism and may function in the normal maintenance of mature organ systems [ 43 44 45 46 ] . In addition, the regenerative healing of vascular and skeletal tissues following acute injuries appears to be aided by re-activating the Hh-signaling cascade [ 47 48 ] . Taken together, these observations suggest that the Hh pathway may represent a point of intervention for treating certain degenerative disorders.
These data show that the Hh-signaling inhibitors, but not structurally related inactive compounds, can significantly compete with the binding of the Hh agonist to Smo-expressing cells.
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